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Interactions betwee...
Interactions between perceived stress and microbial-host immune components : two demographically and geographically distinct pregnancy cohorts
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- Bernabe, Beatriz Penalver (författare)
- Univ Illinois, Coll Engn & Med, Dept Biomed Engn, Chicago, IL 60607 USA.;Univ Illinois, Ctr Bioinformat & Quantitat Biol, Chicago, IL 60607 USA.
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- Maki, Pauline M. (författare)
- Univ Illinois, Coll Med, Dept Psychol, Chicago, IL USA.;Univ Illinois, Coll Med, Dept Psychiat, Chicago, IL USA.;Univ Illinois, Coll Med, Dept Obstet & Gynecol, Chicago, IL 60612 USA.
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- Cunningham, Janet (författare)
- Uppsala universitet,Psykiatri
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- Eisenlohr-Moul, Tory (författare)
- Univ Illinois, Coll Med, Dept Psychol, Chicago, IL USA.;Univ Illinois, Coll Med, Dept Psychiat, Chicago, IL USA.
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- Tussing-Humphreys, Lisa (författare)
- Univ Illinois, Coll Appl Hlth Sci, Dept Kinesiol & Nutr, Chicago, IL USA.
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- Carroll, Ian M. (författare)
- Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27515 USA.
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- Meltzer-Brody, Samantha (författare)
- Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA.
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- Gilbert, Jack A. (författare)
- Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA.;Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA.
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- Kimmel, Mary C. (författare)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27515 USA.
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Univ Illinois, Coll Engn & Med, Dept Biomed Engn, Chicago, IL 60607 USA;Univ Illinois, Ctr Bioinformat & Quantitat Biol, Chicago, IL 60607 USA. Univ Illinois, Coll Med, Dept Psychol, Chicago, IL USA.;Univ Illinois, Coll Med, Dept Psychiat, Chicago, IL USA.;Univ Illinois, Coll Med, Dept Obstet & Gynecol, Chicago, IL 60612 USA. (creator_code:org_t)
- 2023-01-06
- 2023
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 13
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Higher stress during pregnancy associates with negative outcomes and elevated inflammation. The gut microbiota, reflecting environment and social interactions, alongside host immune responses have the potential to better understand perceived stress and identify when stress is excessive in pregnancy. Two U.S. cohorts of 84 pregnant individuals, composed of urban women of color and suburban white women, completed the Perceived Stress Scale-10 (PSS-10) and provided fecal and blood samples at two time points. Confirmatory Factor Analysis assessed the robustness of a two-factor PSS-10 model (Emotional Distress/ED and Self-Efficacy/SE). Gut microbiota composition was measured by 16 S rRNA amplicon sequencing and the immune system activity was assessed with a panel of 21 T-cell related cytokines and chemokines. ED levels were higher in the suburban compared to the urban cohort, but levels of SE were similar. ED and SE levels were associated with distinct taxonomical signatures and the gut microbiota data improved the prediction of SE levels compared with models based on socio-demographic characteristics alone. Integration of self-reported symptoms, microbial and immune information revealed a possible mediation effect of Bacteroides uniformis between the immune system (through CXCL11) and SE. The study identified links between distinct taxonomical and immunological signatures with perceived stress. The data are congruent with a model where gut microbiome and immune factors, both impacting and reflecting factors such as close social relationships and dietary fiber, may modulate neural plasticity resulting in increased SE during pregnancy. The predictive value of these peripheral markers merit further study.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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