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Does inflammation m...
Does inflammation markers or treatment type moderate exercise intensity effects on changes in muscle strength in cancer survivors participating in a 6-month combined resistance- and endurance exercise program? : Results from the Phys-Can trial
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- Henriksson, Anna (författare)
- Uppsala universitet,Livsstil och rehabilitering vid långvarig sjukdom,Uppsala University,Uppsala Univ, Sweden,Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
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- Strandberg, Emelie (författare)
- Uppsala universitet,Livsstil och rehabilitering vid långvarig sjukdom,Uppsala University,Uppsala Univ, Sweden,Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
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- Stenling, Andreas, 1982- (författare)
- Umeå universitet,Institutionen för psykologi,Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway
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- Mazzoni, Anne-Sophie (författare)
- Uppsala universitet,Livsstil och rehabilitering vid långvarig sjukdom,Uppsala University,Uppsala Univ, Sweden,Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
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- Sjövall, Katarina (författare)
- Faculty of Health Science,Man - Health - Society (MHS),Department of Nursing and Integrated Health Sciences,Fakulteten för hälsovetenskap,Människa - Hälsa - Samhälle (MHS),Avdelningen för sjuksköterskeutbildningarna och integrerad hälsovetenskap,Kristianstad Univ, Sweden,Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden
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- Börjeson, Sussanne (författare)
- Linköpings universitet,Avdelningen för omvårdnad och reproduktiv hälsa,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US,Department of Oncology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
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- Raastad, Truls (författare)
- University of Agder,Norwegian School of Sport Sciences,Univ Agder, Norway; Norwegian Sch Sport Sci, Norway,Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway; Department of Physical Performance, Norwegian School of Sport Science, Oslo, Norway
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- Demmelmaier, Ingrid, 1960- (författare)
- Uppsala universitet,Livsstil och rehabilitering vid långvarig sjukdom,Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden; Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway,Uppsala University,University of Agder,Uppsala Univ, Sweden; Univ Agder, Norway
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- Berntsen, Sveinung (författare)
- Uppsala universitet,Livsstil och rehabilitering vid långvarig sjukdom,Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden; Department of Sport Science and Physical Education, University of Agder, Kristiansand, Norway,Uppsala University,University of Agder,Uppsala Univ, Sweden; Univ Agder, Norway
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- Nordin, Karin (författare)
- Uppsala universitet,Livsstil och rehabilitering vid långvarig sjukdom,Uppsala University,Uppsala Univ, Sweden,Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2023-01-19
- 2023
- Engelska.
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Ingår i: BMC Sports Science, Medicine and Rehabilitation. - : BioMed Central (BMC). - 2052-1847. ; 15:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Resistance exercise has a beneficial impact on physical function for patients receiving oncological treatment. However, there is an inter-individual variation in the response to exercise and the tolerability to high-intensity exercise. Identifying potential moderating factors, such as inflammation and treatment type, for changes in muscle strength is important to improve the effectiveness of exercise programs. Therefore, we aimed to investigate if inflammation and type of oncological treatment moderate the effects of exercise intensity (high vs. low-moderate) on muscular strength changes in patients with breast (BRCA) or prostate cancer (PRCA).METHODS: Participants with BRCA (n = 286) and PRCA (n = 65) from the Physical training and Cancer study (Phys-Can) were included in the present study. Participants performed a combined resistance- and endurance exercise program during six months, at either high or low-moderate intensity. Separate regression models were estimated for each cancer type, with and without interaction terms. Moderators included in the models were treatment type (i.e., neo/adjuvant chemotherapy-yes/no for BRCA, adjuvant androgen deprivation therapy (ADT)-yes/no for PRCA)), and inflammation (interleukin 6 (IL6) and tumor necrosis factor-alpha (TNFα)) at follow-up.RESULTS: For BRCA, neither IL6 (b = 2.469, 95% CI [- 7.614, 12.552]) nor TNFα (b = 0.036, 95% CI [- 6.345, 6.418]) levels moderated the effect of exercise intensity on muscle strength change. The same was observed for chemotherapy treatment (b = 4.893, 95% CI [- 2.938, 12.724]). Similarly, for PRCA, the effect of exercise intensity on muscle strength change was not moderated by IL6 (b = - 1.423, 95% CI [- 17.894, 15.048]) and TNFα (b = - 1.905, 95% CI [- 8.542, 4.732]) levels, nor by ADT (b = - 0.180, 95% CI [- 11.201, 10.841]).CONCLUSIONS: The effect of exercise intensity on muscle strength is not moderated by TNFα, IL6, neo/adjuvant chemotherapy, or ADT, and therefore cannot explain any intra-variation of training response regarding exercise intensity (e.g., strength gain) for BRCA or PRCA in this setting.TRIAL REGISTRATION: ClinicalTrials.gov NCT02473003.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Nyckelord
- Androgen deprivation therapy
- Cancer
- Chemotherapy
- Exercise intensity
- Inflammation
- Moderators
- Resistance training
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Henriksson, Anna
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Strandberg, Emel ...
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Stenling, Andrea ...
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Mazzoni, Anne-So ...
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Sjövall, Katarin ...
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Börjeson, Sussan ...
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Raastad, Truls
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Demmelmaier, Ing ...
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Berntsen, Sveinu ...
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Nordin, Karin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Idrottsvetenskap
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BMC Sports Scien ...
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Uppsala universitet
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Högskolan Kristianstad
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Linköpings universitet
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Umeå universitet