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T cell receptor gen...
T cell receptor gene repertoire profiles in subgroups of patients with chronic lymphocytic leukemia bearing distinct genomic aberrations
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- Vlachonikola, Elisavet (författare)
- Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.;Aristotle Univ Thessaloniki, Sch Biol, Dept Genet Dev & Mol Biol, Thessaloniki, Greece.
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- Pechlivanis, Nikolaos (författare)
- Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.;Aristotle Univ Thessaloniki, Sch Biol, Dept Genet Dev & Mol Biol, Thessaloniki, Greece.
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- Karakatsoulis, Georgios (författare)
- Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.;Univ Ioannina, Sch Sci, Dept Math, Ioannina, Greece.
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- Sofou, Electra (författare)
- Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.;Aristotle Univ Thessaloniki, Sch Med, Lab Biol Chem, Thessaloniki, Greece.
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- Gkoliou, Glykeria (författare)
- Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.;Democritus Univ Thrace, Dept Med, Alexandroupolis, Greece.
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- Jeromin, Sabine (författare)
- MLL Munich Leukemia Lab, Munich, Germany.
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- Stavroyianni, Niki (författare)
- G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, Hematopoiet Cell Transplantat HCT Unit, Thessaloniki, Greece.
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- Ranghetti, Pamela (författare)
- Univ Vita Salute San Raffaele, Div Expt Oncol, Milan, Italy.;Osped San Raffaele, IRCCS, Milan, Italy.
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- Scarfo, Lydia (författare)
- Univ Vita Salute San Raffaele, Div Expt Oncol, Milan, Italy.;Osped San Raffaele, IRCCS, Milan, Italy.
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- Österholm, Cecilia (författare)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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- Mansouri, Larry (författare)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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- Notopoulou, Sofia (författare)
- Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.
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- Siorenta, Alexandra (författare)
- Gen Hosp Athens G Gennimatas, Immunol Dept, Sci Life Lab, Athens, Greece.
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- Anagnostopoulos, Achilles (författare)
- G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, Hematopoiet Cell Transplantat HCT Unit, Thessaloniki, Greece.
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- Ghia, Paolo (författare)
- Univ Vita Salute San Raffaele, Div Expt Oncol, Milan, Italy.;Osped San Raffaele, IRCCS, Milan, Italy.
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- Haferlach, Claudia (författare)
- MLL Munich Leukemia Lab, Munich, Germany.
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- Rosenquist, Richard (författare)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Clin Genet, Solna, Sweden.
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- Psomopoulos, Fotis (författare)
- Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.
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- Kouvatsi, Anastasia (författare)
- Aristotle Univ Thessaloniki, Sch Biol, Dept Genet Dev & Mol Biol, Thessaloniki, Greece.
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- Baliakas, Panagiotis, 1977- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin
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- Stamatopoulos, Kostas (författare)
- Karolinska Institutet,Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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- Chatzidimitriou, Anastasia (författare)
- Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece;Aristotle Univ Thessaloniki, Sch Biol, Dept Genet Dev & Mol Biol, Thessaloniki, Greece. Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.;Univ Ioannina, Sch Sci, Dept Math, Ioannina, Greece. (creator_code:org_t)
- 2023-02-01
- 2023
- Engelska.
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Ingår i: Frontiers in Oncology. - : Frontiers Media S.A.. - 2234-943X. ; 13
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Microenvironmental interactions of the malignant clone with T cells are critical throughout the natural history of chronic lymphocytic leukemia (CLL). Indeed, clonal expansions of T cells and shared clonotypes exist between different CLL patients, strongly implying clonal selection by antigens. Moreover, immunogenic neoepitopes have been isolated from the clonotypic B cell receptor immunoglobulin sequences, offering a rationale for immunotherapeutic approaches. Here, we interrogated the T cell receptor (TR) gene repertoire of CLL patients with different genomic aberration profiles aiming to identify unique signatures that would point towards an additional source of immunogenic neoepitopes for T cells.Experimental design: TR gene repertoire profiling using next generation sequencing in groups of patients with CLL carrying one of the following copy-number aberrations (CNAs): del(11q), del(17p), del(13q), trisomy 12, or gene mutations in TP53 or NOTCH1.Results: Oligoclonal expansions were found in all patients with distinct recurrent genomic aberrations; these were more pronounced in cases bearing CNAs, particularly trisomy 12, rather than gene mutations. Shared clonotypes were found both within and across groups, which appeared to be CLL-biased based on extensive comparisons against TR databases from various entities. Moreover, in silico analysis identified TR clonotypes with high binding affinity to neoepitopes predicted to arise from TP53 and NOTCH1 mutations.Conclusions: Distinct TR repertoire profiles were identified in groups of patients with CLL bearing different genomic aberrations, alluding to distinct selection processes. Abnormal protein expression and gene dosage effects associated with recurrent genomic aberrations likely represent a relevant source of CLL-specific selecting antigens.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- T cell receptor (TR) gene repertoire
- chronic lymphocytic leukemia (CLL)
- recurrent genomic aberrations
- neoepitopes
- T cell based immunotherapies
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- Av författaren/redakt...
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Vlachonikola, El ...
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Pechlivanis, Nik ...
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Karakatsoulis, G ...
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Sofou, Electra
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Gkoliou, Glykeri ...
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Jeromin, Sabine
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visa fler...
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Stavroyianni, Ni ...
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Ranghetti, Pamel ...
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Scarfo, Lydia
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Österholm, Cecil ...
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Mansouri, Larry
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Notopoulou, Sofi ...
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Siorenta, Alexan ...
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Anagnostopoulos, ...
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Ghia, Paolo
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Haferlach, Claud ...
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Rosenquist, Rich ...
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Psomopoulos, Fot ...
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Kouvatsi, Anasta ...
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Baliakas, Panagi ...
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Stamatopoulos, K ...
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Chatzidimitriou, ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
- Artiklar i publikationen
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Frontiers in Onc ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet