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Haematological mali...
Haematological malignancies in patients with psoriatic arthritis overall and treated with TNF inhibitors : a Nordic cohort study
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- Cordtz, Rene Lindholm (author)
- Aalborg Univ Hosp, Ctr Rheumat Res Aalborg, Aalborg, Denmark
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- Askling, Johan (author)
- Karolinska Institutet
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- Delcoigne, Benedicte (author)
- Karolinska Institutet
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- Smedby, Karin E. (author)
- Karolinska Institutet
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- Baecklund, Eva, 1956- (author)
- Uppsala universitet,Reumatologi
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- Ballegaard, Christine (author)
- Univ Copenhagen, Bispebjerg & Frederiksberg Hosp, Parker Inst, Copenhagen, Denmark
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- Isomaki, Pia (author)
- Tampere Univ Hosp, Ctr Rheumatol, Tampere, Finland.;Fac Med & Hlth Technol, Tampere, Finland
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- Aaltonen, Kalle (author)
- Minist Social Affairs & Hlth, Pharmaceut Pricing Board, ROB FIN, Helsinki, Finland
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- Gudbjornsson, Bjorn (author)
- Univ Iceland, Landspitali Univ Hosp Iceland, Ctr Rheumatol Res, Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland
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- Love, Thorvardur Jon (author)
- Univ Iceland, Fac Med, Reykjavik, Iceland.;Landspitali Univ Hosp Iceland, Dept Sci, Reykjavik, Iceland
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- Provan, Sella Aarrestad (author)
- Diakonhjemmet Hosp, Ctr Treatment Rheumat & Musculoskeletal Dis REMED, Oslo, Norway
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- Michelsen, Brigitte (author)
- Diakonhjemmet Hosp, Ctr Treatment Rheumat & Musculoskeletal Dis REMED, Oslo, Norway.;Sorlandet Hosp Kristiansand, Div Rheumatol, Kristiansand, Norway
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- Sexton, Joseph (author)
- Diakonhjemmet Hosp, Ctr Treatment Rheumat & Musculoskeletal Dis REMED, Oslo, Norway
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- Dreyer, Lene (author)
- Aalborg Univ Hosp, Ctr Rheumat Res Aalborg, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark
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- Hellgren, Karin (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-12-23
- 2022
- English.
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In: RMD Open. - : BMJ Publishing Group Ltd. - 2056-5933. ; 8:2
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- Objectives To evaluate the risk of haematological malignancies in patients with psoriatic arthritis (PsA) overall, and in relation to treatment with tumour necrosis factor inhibitors (TNFi).Methods We identified that patients with PsA starting a first TNFi from the clinical rheumatology registers (CRR) in the five Nordic countries (n=10 621) and biologics-naive PsA patients from (1) the CRR (n=18 705) and (2) the national patient registers (NPR, n=27 286, Sweden and Denmark) from 2006 through 2019. For Sweden and Denmark, general population comparators were matched 5:1 to PsA patients on birth year, year at start of follow-up and sex. By linkage to the national cancer registers in all countries, we collected information on haematological malignancies overall, and categorised into lymphoid or myeloid types. We estimated incidence rate ratios (IRRs) with 95% CIs using modified Poisson regression for TNFi-treated versus biologics-naive PsA patients and versus the general population adjusted for age, sex, calendar period and country.Results During 59 827 person-years, 40 haematological malignancies occurred among TNFi-treated patients with PsA resulting in a pooled IRR of 0.96 (0.68-1.35) versus biologics-naive PsA from CRR and an IRR of 0.84 (0.64-1.10) versus biologics-naive PsA from NPR. The IRR of haematological malignancies in PsA overall versus general population comparators was 1.35 (1.17-1.55). The estimates were largely similar for lymphoid and myeloid malignancies.Conclusions Treatment with TNFi in patients with PsA was not associated with an increased incidence of haematological malignancies. Conversely, a moderately increased underlying risk was seen in patients with PsA compared with the general population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
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- ref (subject category)
- art (subject category)
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Cordtz, Rene Lin ...
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Askling, Johan
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Delcoigne, Bened ...
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Smedby, Karin E.
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Baecklund, Eva, ...
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Ballegaard, Chri ...
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Isomaki, Pia
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Aaltonen, Kalle
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Gudbjornsson, Bj ...
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Love, Thorvardur ...
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Provan, Sella Aa ...
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Michelsen, Brigi ...
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Sexton, Joseph
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Dreyer, Lene
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Hellgren, Karin
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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RMD Open
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Uppsala University
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Karolinska Institutet