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Biochemical Associa...
Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor
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- Mallhi, Tauqeer Hussain (författare)
- Jouf Univ, Coll Pharm, Dept Clin Pharm, Sakaka 72388, Saudi Arabia.
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- Shahid, Momina (författare)
- Univ Faisalabad, Dept Pharm, Faisalabad 38000, Pakistan.;Govt Coll Univ, Dept Pharmaceut Chem, Faisalabad 38000, Pakistan.
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- Rehman, Kanwal (författare)
- Women Univ, Dept Pharm, Multan 60000, Pakistan.
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- Khan, Yusra Habib (författare)
- Jouf Univ, Coll Pharm, Dept Clin Pharm, Sakaka 72388, Saudi Arabia.
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- Alanazi, Abdullah Salah (författare)
- Jouf Univ, Coll Pharm, Dept Clin Pharm, Sakaka 72388, Saudi Arabia.
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- Alotaibi, Nasser Hadal (författare)
- Jouf Univ, Coll Pharm, Dept Clin Pharm, Sakaka 72388, Saudi Arabia.
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- Akash, Muhammad Sajid Hamid (författare)
- Govt Coll Univ, Dept Pharmaceut Chem, Faisalabad 38000, Pakistan.
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- Hammad Butt, Muhammad (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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Jouf Univ, Coll Pharm, Dept Clin Pharm, Sakaka 72388, Saudi Arabia Univ Faisalabad, Dept Pharm, Faisalabad 38000, Pakistan.;Govt Coll Univ, Dept Pharmaceut Chem, Faisalabad 38000, Pakistan. (creator_code:org_t)
- 2023-02-09
- 2023
- Engelska.
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Ingår i: Metabolites. - : MDPI. - 2218-1989 .- 2218-1989. ; 13:2
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Myocardial infarction (MI) is a cardiovascular disease that occurs due to the blockage of the coronary artery. Subsequently, cardiac muscles receive a lower oxygen supply, which leads to the death of cardiac muscles. The etiology of MI is linked to various environmental, occupational, and genetic factors. Various studies have been conducted on the polymorphism of genes involved in MI. Previous studies have shown that different variants of the methylene tetrahydrofolate reductase (MTHFR) gene are involved in causing MI by altering the metabolism of folate and homocysteine. However, the genetic polymorphism of MTHFR C677T (rs1801133) and its association with MI in the presence of diabetes mellitus (DM) as a risk factor still needs to be investigated. This study recruited 300 participants who were divided into three groups, i.e., the control, MI, and MI-DM. The blood samples collected from the study participants were subjected to various biochemical tests and their clinical parameters were monitored. MTHFR C677T (rs1801133) genotyping was performed by Tetra ARMS PCR using predetermined primers. The MTHFR C677T (rs1801133) polymorphism was associated with MI in the presence of DM as a risk factor among the participants. The MTHFR C677T (rs1801133) T/T homozygous genotype was found to be significant among MI patients in the presence of DM as a risk factor.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Nyckelord
- MTHFR gene polymorphism
- myocardial infarction
- myocardial infarction with diabetes mellitus
- homocysteinemia
- tetra-ARMS PCR
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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