Ongoing evolution of Chlamydia trachomatis lymphogranuloma venereum: exploring the genomic diversity of circulating strains

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: id:"swepub:oai:DiVA.org:uu-502304" > Ongoing evolution o...

1 av 1
Föregående post
Nästa post
Till träfflistan

Ongoing evolution of Chlamydia trachomatis lymphogranuloma venereum : exploring the genomic diversity of circulating strains

Seth-Smith, Helena M. B. (författare): Univ Basel, Univ Hosp Basel, Clin Bacteriol & Mycol, Basel, Switzerland.;Univ Basel, Dept Biomed, Appl Microbiol Res, Basel, Switzerland.;SIB Swiss Inst Bioinformat, Basel, Switzerland.

Benard, Angele (författare): Wellcome Trust Sanger Inst, Cambridge, England.;Univ Autonoma Barcelona, VHIR, Healthcare Syst Res Grp, Passeig Vall dHebron 119-129, Barcelona 08035, Spain.

Bruisten, Sylvia M. (författare): GGD Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Amsterdam, Netherlands.

visa fler...

Versteeg, Bart (författare): GGD Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands.;London Sch Hyg & Trop Med, Clin Res Dept, London, England.

Herrmann, Björn, 1955- (författare): Uppsala universitet,Klinisk mikrobiologi

Kok, Jen (författare): Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW, Australia.;Univ Sydney, Westmead Clin Sch, Sydney, NSW, Australia.;Westmead Hosp, Inst Clin Pathol & Med Res, Ctr Infect Dis & Microbiol Lab Serv, Westmead, NSW, Australia.

Carter, Ian (författare): Westmead Hosp, Inst Clin Pathol & Med Res, Ctr Infect Dis & Microbiol Lab Serv, Westmead, NSW, Australia.

Peuchant, Olivia (författare): CHU Bordeaux, French Natl Reference Ctr Bacterial STIs, Dept Bacteriol, Bordeaux, France.

Bebear, Cecile (författare): CHU Bordeaux, French Natl Reference Ctr Bacterial STIs, Dept Bacteriol, Bordeaux, France.

Lewis, David A. (författare): Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW, Australia.;Univ Sydney, Westmead Clin Sch, Sydney, NSW, Australia.;Western Sydney Local Hlth Dist, Western Sydney Sexual Hlth Ctr, Parramatta, NSW, Australia.

Puerta, Teresa (författare): Hosp Clin San Carlos, Ctr Sanitario Sandoval, Unidad ITS VIH, Inst Invest Sanitaria San Carlos IdISSC, Madrid, Spain.

Kese, Darja (författare): Univ Ljubljana, Inst Microbiol & Immunol, Fac Med, Ljubljana, Slovenia.

Balla, Eszter (författare): Natl Ctr Epidemiol, Bacterial STI Reference Lab, Budapest, Hungary.

Zakoucka, Hana (författare): Natl Inst Publ Hlth, Natl Reference Lab Diagnost Syphilis & Chlamydia, Srobarova 48, Prague 10, Czech Republic.

Rob, Filip (författare): Charles Univ & Hosp Bulovka, Fac Med 2, Dept Dermatovenereol, Budinova 2, Prague 18081 8, Czech Republic.

Morre, Servaas A. (författare): VU Univ Med Ctr Amsterdam, Dept Med Microbiol & Infect Control, Lab Immunogenet, Amsterdam, Netherlands.;Univ Maastricht, Inst Publ Hlth Genom IPHG, Res Inst GROW, Dept Genet & Cell Biol, Maastricht, Netherlands.

de Barbeyrac, Bertille (författare)

Galan, Juan Carlos (författare): Hosp Univ Ramon & Cajal, Inst Ramon & Cajal Invest Sanitaria IRYCIS, Serv Microbiol, Madrid, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Venezuela.

Vries, Henry J. C. (författare): GGD Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands.;Univ Amsterdam, Acad Med Ctr, Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Amsterdam, Netherlands.

Thomson, Nicholas R. (författare): Wellcome Trust Sanger Inst, Cambridge, England.;London Sch Hyg & Trop Med, Clin Res Dept, London, England.

Goldenberger, Daniel (författare): Univ Basel, Univ Hosp Basel, Clin Bacteriol & Mycol, Basel, Switzerland.

Egli, Adrian (författare): Univ Basel, Univ Hosp Basel, Clin Bacteriol & Mycol, Basel, Switzerland.;Univ Basel, Dept Biomed, Appl Microbiol Res, Basel, Switzerland.

visa färre...

Univ Basel, Univ Hosp Basel, Clin Bacteriol & Mycol, Basel, Switzerland;Univ Basel, Dept Biomed, Appl Microbiol Res, Basel, Switzerland.;SIB Swiss Inst Bioinformat, Basel, Switzerland. Wellcome Trust Sanger Inst, Cambridge, England.;Univ Autonoma Barcelona, VHIR, Healthcare Syst Res Grp, Passeig Vall dHebron 119-129, Barcelona 08035, Spain. (creator_code:org_t)

Microbiology Society, 2021
2021
Engelska.
Ingår i: Microbial Genomics. - : Microbiology Society. - 2057-5858. ; 7:6

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Lymphogranuloma venereum (LGV), the invasive infection of the sexually transmissible infection (STI) Chlamydia trachomatis, is caused by strains from the LGV biovar, most commonly represented by ompA- genotypes L2b and L2. We investigated the diversity in LGV samples across an international collection over seven years using typing and genome sequencing. LGV- positive samples (n=321) from eight countries collected between 2011 and 2017 (Spain n=97, Netherlands n=67, Switzerland n=64, Australia n=53, Sweden n=37, Hungary n=31, Czechia n=30, Slovenia n=10) were genotyped for pmpH and ompA variants. All were found to contain the 9 bp insertion in the pmpH gene, previously associated with ompA- genotype L2b. However, analysis of the ompA gene shows ompA- genotype L2b (n=83), ompA- genotype L2 (n=180) and several variants of these (n=52; 12 variant types), as well as other/mixed ompA-genotypes (n=6). To elucidate the genomic diversity, whole genome sequencing (WGS) was performed from selected samples using SureSelect target enrichment, resulting in 42 genomes, covering a diversity of ompA- genotypes and representing most of the countries sampled. A phylogeny of these data clearly shows that these ompA- genotypes derive from an ompA- genotype L2b ancestor, carrying up to eight SNPs per isolate. SNPs within ompA are overrep-resented among genomic changes in these samples, each of which results in an amino acid change in the variable domains of OmpA (major outer membrane protein, MOMP). A reversion to ompA- genotype L2 with the L2b genomic backbone is commonly seen. The wide diversity of ompA- genotypes found in these recent LGV samples indicates that this gene is under immunological selection. Our results suggest that the ompA- genotype L2b genomic backbone is the dominant strain circulating and evolving particularly in men who have sex with men (MSM) populations.

Hitta via bibliotek

Microbial Genomics (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Mikrobiologi ino ...

Artiklar i publikationen: Microbial Genomi ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Ongoing evolution of Chlamydia trachomatis lymphogranuloma venereum : exploring the genomic diversity of circulating strains

Ämnesord

Nyckelord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub