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Depression and 24 g...
Depression and 24 gastrointestinal diseases : a Mendelian randomization study
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- Ruan, Xixian (författare)
- Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.
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- Chen, Jie (författare)
- Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.
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- Sun, Yuhao (författare)
- Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.
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- Zhang, Yao (författare)
- Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Gastroenterol, Shanghai, Peoples R China.
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- Zhao, Jianhui (författare)
- Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.
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- Wang, Xiaoyan (författare)
- Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China.
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- Li, Xue (författare)
- Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.
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- Yuan, Shuai (författare)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
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Cent South Univ, Xiangya Hosp 3, Dept Gastroenterol, Changsha, Peoples R China Zhejiang Univ, Sch Med, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.;Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China. (creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 13
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The causality of the association between depression and gastrointestinal diseases is undetermined. We conducted Mendelian randomization (MR) analyses to systematically explore the associations of depression with 24 gastrointestinal diseases. Independent genetic variants associated with depression at the genome-wide significance level were selected as instrumental variables. Genetic associations with 24 gastrointestinal diseases were obtained from the UK Biobank study, the FinnGen study, and large consortia. Multivariable MR analysis was conducted to explore the mediation effects of body mass index, cigarette smoking, and type 2 diabetes. After multiple-testing corrections, genetic liability to depression was associated with an increased risk of irritable bowel syndrome, non-alcohol fatty liver disease, alcoholic liver disease, gastroesophageal reflux, chronic pancreatitis, duodenal ulcer, chronic gastritis, gastric ulcer, diverticular disease, cholelithiasis, acute pancreatitis, and ulcerative colitis. For the causal effect of genetic liability to depression on non-alcoholic fatty liver disease, a substantial proportion was mediated by body mass index. Genetic predisposition to smoking initiation mediated half of effect of depression on acute pancreatitis. This MR study suggests that depression may play a causal role in many gastrointestinal diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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