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Antiinflammatory an...
Antiinflammatory and antibacterial activities of C-methylflavonols from Piliostigma thonningii
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Ibewuike, Joseph C (författare)
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Ogungbamila, Francis O (författare)
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Ogundaini, Abiodun O (författare)
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Okeke, Irukaku N (författare)
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- Bohlin, Lars (författare)
- Uppsala universitet,Avdelningen för farmakognosi
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: Phytotherapy Research. - 0951-418X .- 1099-1573. ; 11:4, s. 281-284
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Newly described C-methylflavonols, 6,8-di-C-methylquercetin 3-methyl ether, 6-C-methylquercetin 3,7-dimethyl ether, 6,8-di-C-methylquercetin 3,7-dimethyl ether together with the known compounds quercetin, quercitrin, 6-C-methylquercetin 1-methyl ether, 6-C-methylquercetin 3,7,3'-trimethyl ether, 6,8-di-C-methylkaempferoI 3-methyl ether and 6,8-di-C-methylkaempferol 3,7-dimethyl ether isolated from the leaves of Piliostigma thonningii, were tested for their ability to inhibit prostaglandin synthesis in vitro and antibacterial activity against Staph, aureus, The influence of the B ring 3',4' diol group on the activity of C-methylflavonols in the inhibition of prostaglandin synthesis differ from that observed for a series of flavonoids without C-methyl groups, The antibacterial activity in the series mirror those of methylated antimicrobial flavonoids, The traditional uses of the plant in infections and inflammatory conditions were rationalized on the basis of the activities of these compounds.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Piliostigma thonningii
- Caesalpiniaceae
- C-methylflavonols
- prostaglandin synthesis inhibition
- antibacterial activities
- PHARMACY
- FARMACI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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