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Correlation between...
Correlation between cognitive assessment scores and circulating cerebral biomarkers in women with pre-eclampsia and eclampsia
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- Bokström-Res, Emma (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Hastie, Roxanne (författare)
- Uppsala universitet,Klinisk obstetrik,Univ Melbourne, Dept Obstet & Gynaecol, Translat Obstet Grp, Melbourne, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.
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- Schell, Sonja (författare)
- Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa.
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- Cluver, Catherine (författare)
- Univ Melbourne, Dept Obstet & Gynaecol, Translat Obstet Grp, Melbourne, Vic, Australia.;Mercy Hosp Women, Mercy Perinatal, Heidelberg, Vic, Australia.;Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa.
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- Bergman, Lina (författare)
- Gothenburg University,Göteborgs universitet,Uppsala universitet,Klinisk obstetrik,Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Obstet & Gynaecol, Gothenburg, Sweden.;Stellenbosch Univ, Dept Obstet & Gynecol, Cape Town, South Africa.,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Pregnancy Hypertension. - : Elsevier. - 2210-7789 .- 2210-7797. ; 31, s. 38-45
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Objectives: The cerebral injury biomarkers neurofilament light chain (NfL) and tau and the glial activation biomarker glial fibrillary acidic protein (GFAP) may reflect neurological injury in pre-eclampsia. We assessed if there was a correlation between cognitive function assessment scores and plasma concentrations of these biomarkers in pre-eclampsia.Study design: Women with eclampsia, pre-eclampsia and normotensive pregnancies from the South African PROVE biobank were included. Blood samples were taken at inclusion. The Montreal Cognitive Assessment was performed after delivery at the time of discharge. The correlation between cognitive assessment scores and plasma concentrations of cerebral biomarkers was analysed using Spearman correlation adjusted for time from eclamptic seizure.Main outcome measures: We included 49 women with eclampsia, 16 women with pre-eclampsia complicated by pulmonary oedema, 22 women with pre-eclampsia without pulmonary oedema, HELLP or neurological complications and 18 women with normotensive pregnancies.Results: There was a correlation between impaired cognitive function and increased plasma concentrations of NfL in women with eclampsia and women with pre-eclampsia and pulmonary oedema (r = -0.37, p = 0.009 and r = -0.56, p = 0.025 respectively). No correlation between impaired cognitive function and NfL in pre-eclampsia cases without pulmonary oedema, HELLP or neurological complications or normotensive pregnancies was found. No correlation with cognitive impairment was found in any groups for tau or GFAP.Conclusions: We found a correlation between impaired cognitive function assessment and plasma NfL concentrations in women with eclampsia and pre-eclampsia complicated by pulmonary oedema. These findings suggest that acute neuroaxonal injury may cause or contribute to cognitive impairment in these women.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Pre-eclampsia
- Cerebral biomarkers
- Cognition
- Cognitive assessment
- Cerebral biomarkers
- Cognition
- Cognitive assessment
- Pre-eclampsia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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