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Fish skin gelatin-b...
Fish skin gelatin-based adhesive hydrogels loading cod peptides with osteogenic activity for bone tissue engineering
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- Ma, Wuchao (författare)
- Dalian Polytech Univ, Sch Food Sci & Technol, Natl Engn Res Ctr Seafood, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China.
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- Yang, Meilian (författare)
- Dalian Polytech Univ, Sch Food Sci & Technol, Natl Engn Res Ctr Seafood, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China.
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- Wu, Di (författare)
- Dalian Polytech Univ, Sch Food Sci & Technol, Natl Engn Res Ctr Seafood, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China.
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- Li, Yao (författare)
- Dalian Polytech Univ, Sch Light Ind & Chem Engn, Dalian 116034, Peoples R China.
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- Wang, Li-Shu (författare)
- Med Coll Wisconsin, Dept Med, Div Hematol & Oncol, Milwaukee, WI 53226 USA.
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- El-Seedi, Hesham (författare)
- Uppsala universitet,Farmakognosi
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- Wu, Chao (författare)
- Dalian Polytech Univ, Sch Food Sci & Technol, Natl Engn Res Ctr Seafood, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China.
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- Du, Ming (författare)
- Dalian Polytech Univ, Sch Food Sci & Technol, Natl Engn Res Ctr Seafood, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China.
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Dalian Polytech Univ, Sch Food Sci & Technol, Natl Engn Res Ctr Seafood, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China Dalian Polytech Univ, Sch Light Ind & Chem Engn, Dalian 116034, Peoples R China. (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Colloids and Surfaces A. - : Elsevier. - 0927-7757 .- 1873-4359. ; 673
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Loading bioactive molecules, such as proteins and peptides, into hydrogels is a promising strategy to expand the application of hydrogels in tissue engineering. Herein, a novel bioactive gelatin hydrogel loading peptide derived from Atlantic cod (Gadus morhua) was developed for bone tissue engineering, which was constructed on the NaIO4-mediated oxidative coupling of dopamine-modified gelatin (Gel-DA). The Gel-DA hydrogel incorporated with cod peptides (0.5 mg/mL) showed an acceptable gelation time (130.22 & PLUSMN; 7.15 s) and maintained a continuous microscopic pore structure. Besides, the compression strength and adhesive strength of Gel-DA hydrogel with 0.5 mg/mL cod peptides reached 136.33 & PLUSMN; 38.95 kPa and 4.93 & PLUSMN; 0.80 kPa, respectively. Meanwhile, all hydrogels exhibited excellent mechanical stability. The incorporation of cod peptides (0.1, 0.5 mg/mL) was beneficial to the adhesion and spreading of mouse osteoblasts precursor cells MC3T3-E1. Moreover, the alkaline phosphatase (ALP) activity of the Gel-DA hydrogel loading 0.5 mg/mL peptides was significantly increased from 0.16 & PLUSMN; 0.02 U.mg/protein to 0.19 & PLUSMN; 0.02 U.mg/protein as compared to Gel-DA hydrogel. These results indicated that the GD-CPs hydrogel is an effective candidate material for bone tissue engineering.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- Gelatin
- Dopamine
- Hydrogel
- Cod peptides
- Bone tissue engineering
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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