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Reducing intrusive ...
Reducing intrusive memories after trauma via an imagery-competing task intervention in COVID-19 intensive care staff : a randomised controlled trial
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- Iyadurai, Lalitha (författare)
- P1vital Prod Ltd, Wallingford, Oxon, England.
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- Highfield, Julie (författare)
- Intens Care Soc, 7-9-Breams Bldg, London, England.
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- Kanstrup, Marie (författare)
- Uppsala universitet,Institutionen för psykologi
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- Markham, Alfred (författare)
- P1vital Prod Ltd, Wallingford, Oxon, England.
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- Ramineni, Varsha (författare)
- Uppsala universitet,Institutionen för psykologi,P1vital Prod Ltd, Wallingford, Oxon, England.
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- Guo, Boliang (författare)
- NIHR ARC East Midlands, Nottingham, England.
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- Jaki, Thomas (författare)
- Univ Cambridge, MRC Biostat Unit, Cambridge, Cambs, England.;Univ Regensburg, Regensburg, Bavaria, Germany.
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- Kingslake, Jonathan (författare)
- P1vital Prod Ltd, Wallingford, Oxon, England.
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- Goodwin, Guy M. (författare)
- Univ Oxford, Dept Psychiat, Oxford, Oxon, England.
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- Summers, Charlotte (författare)
- Univ Cambridge, Heart & Lung Res Inst, Cambridge, Cambs, England.
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- Bonsall, Michael B. (författare)
- Univ Oxford, Dept Biol, Oxford, Oxon, England.
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- Holmes, Emily A. (författare)
- Uppsala universitet,Institutionen för psykologi
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P1vital Prod Ltd, Wallingford, Oxon, England Intens Care Soc, 7-9-Breams Bldg, London, England. (creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 13:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Intrusive memories (IMs) after traumatic events can be distressing and disrupt mental health and functioning. We evaluated the impact of a brief remotely-delivered digital imagery-competing task intervention on the number of IMs for intensive care unit (ICU) staff who faced repeated trauma exposure during the COVID-19 pandemic using a two-arm, parallel-group, single-blind randomised controlled trial, with the comparator arm receiving delayed access to active treatment (crossover). Eligible participants worked clinically in a UK NHS ICU during the pandemic and had at least 3 IMs of work-related traumatic events in the week before recruitment. Participants were randomly assigned (1:1) to immediate (weeks 1-4) or delayed (weeks 5-8) intervention access. Sequential Bayesian analyses to optimise the intervention and increase trial efficiency are reported elsewhere [1]. The primary endpoint for the pre-specified frequentist analysis of the final study population compared the number of IMs experienced in week 4 between the immediate and delayed access arms. Secondary outcomes included clinical symptoms, work functioning and wellbeing. Safety was assessed throughout the trial by scheduled questions and free report. All analyses were undertaken on an intention-to-treat basis (86 randomised participants). There were significantly fewer intrusive memories during week 4 in the immediate (median = 1, IQR = 0-3, n = 43), compared to the comparator delayed arm (median = 10, IQR = 6-17, n = 43), IRR 0.31, 95% CI: 0.20-0.48, p < 0.001. After crossover, the delayed arm also showed a significant reduction in IMs at week 8 compared to week 4. There were convergent findings for symptoms of PTSD, insomnia and anxiety, work engagement and burnout, general functioning and quality of life. The intervention was found safe and acceptable to participants. All adverse events were unrelated to the study. Our study provides the first evidence of a benefit on reducing IMs, improving other clinical symptoms, work functioning and wellbeing, as well as safety of a brief remotely-delivered digital imagery-competing task intervention. An efficacy trial with an active control and longer follow-up is warranted. The trial is registered at ClinicalTrials.gov (NCT04992390).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Iyadurai, Lalith ...
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Highfield, Julie
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Kanstrup, Marie
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Markham, Alfred
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Ramineni, Varsha
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Guo, Boliang
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visa fler...
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Jaki, Thomas
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Kingslake, Jonat ...
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Goodwin, Guy M.
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Summers, Charlot ...
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Bonsall, Michael ...
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Holmes, Emily A.
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visa färre...
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