id:"swepub:oai:DiVA.org:uu-514762"
Sökning: id:"swepub:oai:DiVA.org:uu-514762" > Helicobacter pylori...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Helicobacter pylori and Pro-Inflammatory Protein Biomarkers in Myocardial Infarction with and without Obstructive Coronary Artery Disease
-
- Warme, Jonatan (författare)
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
-
- Sundqvist, Martin O. (författare)
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden.
-
- Hjort, Marcus (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
- visa fler...
- visa färre...
- Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden;Soder Sjukhuset, Dept Cardiol, SE-11883 Stockholm, Sweden. Uppsala kliniska forskningscentrum (UCR) (creator_code:org_t)
- MDPI AG, 2023
- 2023
- Engelska.
- Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 44
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Myocardial infarction (MI) with obstructive coronary artery disease (MI-CAD) and MI in the absence of obstructive coronary artery disease (MINOCA) affect different populations and may have separate pathophysiological mechanisms, with greater inflammatory activity in MINOCA compared to MI-CAD. Helicobacter pylori (Hp) can cause systemic inflammation and has been associated with cardiovascular disease (CVD). We aimed to investigate whether Hp infection is associated with concentrations of protein biomarkers of inflammation and CVD. In a case-control study, patients with MINOCA (n = 99) in Sweden were included, complemented by matched subjects with MI-CAD (n = 99) and controls (n = 100). Protein biomarkers were measured with a proximity extension assay in plasma samples collected 3 months after MI. The seroprevalence of Hp and cytotoxin-associated gene A (CagA) was determined using ELISA. The associations between protein levels and Hp status were studied with linear regression. The prevalence of Hp was 20.2%, 19.2%, and 16.0% for MINOCA, MI-CAD, and controls, respectively (p = 0.73). Seven proteins were associated with Hp in an adjusted model: tissue plasminogen activator (tPA), interleukin-6 (IL-6), myeloperoxidase (MPO), TNF-related activation-induced cytokine (TRANCE), pappalysin-1 (PAPPA), soluble urokinase plasminogen activator receptor (suPAR), and P-selectin glycoprotein ligand 1 (PSGL-1). Hp infection was present in one in five patients with MI, irrespective of the presence of obstructive CAD. Inflammatory proteins were elevated in Hp-positive subjects, thus not ruling out that Hp may promote an inflammatory response and potentially contribute to the development of CVD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- myocardial infarction
- coronary artery disease
- MINOCA
- Helicobacter pylori
- inflammation
- biomarkers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
- International Journal of Molecular Sciences (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Warme, Jonatan
- Sundqvist, Marti ...
- Hjort, Marcus
- Agewall, Stefan
- Collste, Olov
- Ekenback, Christ ...
- visa fler...
- Frick, Mats
- Henareh, Loghman
- Hofman-Bang, Cla ...
- Spaak, Jonas
- Sorensson, Peder
- Y-Hassan, Shams
- Svensson, Per
- Lindahl, Bertil, ...
- Hofmann, Robin
- Tornvall, Per
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Kardiologi
- Artiklar i publikationen
- International Jo ...
- EUROPEAN HEART J ...
- Av lärosätet
- Uppsala universitet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
