id:"swepub:oai:DiVA.org:uu-515045"
Sökning: id:"swepub:oai:DiVA.org:uu-515045" > Anti-inflammatory a...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3-seco-Tirucallane Triterpenoids Meliadubins A and B from Melia dubia Cav. Barks with ChemGPS-NP and In Silico Prediction
-
- Trung, Hieu Tran (författare)
- Vinh Univ, Dept Chem, Vinh City 462030, Vietnam.
-
- Purnomo, Kartiko Arif (författare)
- Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807378, Taiwan.
-
- Yu, Szu-Yin (författare)
- Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807378, Taiwan.;Univ Szeged, Inst Pharmacognosy, H-6720 Szeged, Hungary.
- visa fler...
- visa färre...
- Vinh Univ, Dept Chem, Vinh City 462030, Vietnam Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807378, Taiwan. (creator_code:org_t)
- American Chemical Society (ACS), 2023
- 2023
- Engelska.
- Ingår i: ACS Omega. - : American Chemical Society (ACS). - 2470-1343. ; 8:40, s. 37116-37127
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Two new rearranged 2,3-seco-tirucallane triterpenoids, meliadubins A (1) and B (2), along with four known compounds, 3-6, were isolated from the barks of Melia dubia Cav. Compound 2 exhibited a significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC50 at 5.54 +/- 0.36 mu M). It bound to active sites of a human inducible nitric oxide synthase (3E7G) through interactions with the residues of GLU377 and PRO350, which may benefit in reducing the neutrophilic inflammation effect. The ChemGPS-NP interpretation combined with bioactivity assay and in silico prediction results suggested 2 to be an agent for targeting iNOS with different mechanisms as compared to a selected set of current approved drugs. Moreover, compounds 1 and 2 showed remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae in a dose-dependent manner with IC50 values of 137.20 +/- 9.55 and 182.50 +/- 18.27 mu M, respectively. Both 1 and 2 displayed interactions with the residue of TYR223, a key active site of trihydroxynaphthalene reductase (1YBV). The interpretation of 1 and 2 in the ChemGPS-NP physical-chemical property space indicated that both compounds are quite different compared to all members of a selected set of reference compounds. In light of demonstrated biological activity and in silico prediction experiments, both compounds possibly exhibited activity against phytopathogenic fungi via a novel mode of action.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Trung, Hieu Tran
- Purnomo, Kartiko ...
- Yu, Szu-Yin
- Yang, Zih-Jie
- Hu, Hao-Chun
- Hwang, Tsong-Lon ...
- visa fler...
- Tuan, Nguyen Ngo ...
- Tu, Le Ngoc
- Duc, Dau Xuan
- Quang, Le Dang
- Backlund, Anders ...
- Thang, Tran Dinh
- Chang, Fang-Rong
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Farmakologi och ...
- Artiklar i publikationen
- ACS Omega
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
