Sökning: id:"swepub:oai:DiVA.org:uu-516881" >
Levels of inflammat...
Levels of inflammatory cytokines MCP-1, CCL4, and PD-L1 in CSF differentiate idiopathic normal pressure hydrocephalus from neurodegenerative diseases
-
- Braun, Madelen (författare)
- Uppsala universitet,Neurologi
-
- Boström, Gustaf (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Molekylär geriatrik
-
- Ingelsson, Martin (författare)
- Uppsala universitet,Molekylär geriatrik,Univ Hlth Network, Krembil Brain Inst, Toronto, ON, Canada.;Univ Toronto, Dept Med, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada.;Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
-
visa fler...
-
- Kilander, Lena (författare)
- Uppsala universitet,Molekylär geriatrik
-
- Löwenmark, Malin, 1969- (författare)
- Uppsala universitet,Molekylär geriatrik
-
- Nyholm, Dag, Professor, 1974- (författare)
- Uppsala universitet,Neurologi
-
- Burman, Joachim, 1974- (författare)
- Uppsala universitet,Neurologi
-
- Niemelä, Valter (författare)
- Uppsala universitet,Neurologi
-
- Freyhult, Eva, 1979- (författare)
- Uppsala universitet,Beräkningsbiologi och bioinformatik
-
- Kultima, Kim (författare)
- Uppsala universitet,Klinisk kemi
-
- Virhammar, Johan (författare)
- Uppsala universitet,Neurologi
-
visa färre...
-
(creator_code:org_t)
- BioMed Central (BMC), 2023
- 2023
- Engelska.
-
Ingår i: Fluids and Barriers of the CNS. - : BioMed Central (BMC). - 2045-8118. ; 20
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Neuroinflammatory processes have been suggested to play a role in the pathophysiology of neurodegenerative diseases and post-hemorrhagic hydrocephalus, but have rarely been investigated in patients with idiopathic normal pressure hydrocephalus (iNPH). The aim of this study was to investigate whether levels of inflammatory proteins in CSF are different in iNPH compared to healthy controls and patients with selected neurodegenerative disorders, and whether any of these markers can aid in the differential diagnosis of iNPH.Methods: Lumbar CSF was collected from 172 patients from a single center and represented iNPH (n = 74), Alzheimer's disease (AD) (n = 21), mild cognitive impairment (MCI) due to AD (n = 21), stable MCI (n = 22), frontotemporal dementia (n = 13), and healthy controls (HC) (n = 21). Levels of 92 inflammatory proteins were analyzed using a proximity extension assay. As a first step, differences between iNPH and HC were investigated, and proteins that differed between iNPH and HC were then compared with those from the other groups. The linear regressions were adjusted for age, sex, and plate number.Results: Three proteins showed higher (MCP-1, p = 0.0013; CCL4, p = 0.0008; CCL11, p = 0.0022) and one lower (PD-L1, p = 0.0051) levels in patients with iNPH compared to HC. MCP-1 was then found to be higher in iNPH than in all other groups. CCL4 was higher in iNPH than in all other groups, except in MCI due to AD. PD-L1 was lower in iNPH compared to all other groups, except in stable MCI. Levels of CCL11 did not differ between iNPH and the differential diagnoses. In a model based on the four proteins mentioned above, the mean area under the receiver operating characteristic curve used to discriminate between iNPH and the other disorders was 0.91.Conclusions: The inflammatory cytokines MCP-1 and CCL4 are present at higher-and PD-L1 at lower-levels in iNPH than in the other investigated diagnoses. These three selected cytokines may have diagnostic potential in the work-up of patients with iNPH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Normal pressure hydrocephalus
- MCP-1
- CCL4
- PD-L1
- Biomarkers
- Cerebrospinal fluid
- Neuroinflammation
- Proteomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Braun, Madelen
-
Boström, Gustaf
-
Ingelsson, Marti ...
-
Kilander, Lena
-
Löwenmark, Malin ...
-
Nyholm, Dag, Pro ...
-
visa fler...
-
Burman, Joachim, ...
-
Niemelä, Valter
-
Freyhult, Eva, 1 ...
-
Kultima, Kim
-
Virhammar, Johan
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
- Artiklar i publikationen
-
Fluids and Barri ...
- Av lärosätet
-
Uppsala universitet