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Plasma levels of pe...
Plasma levels of per- and polyfluoroalkyl substances (PFAS) and cardiovascular disease - Results from two independent population-based cohorts and a meta-analysis
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- Dunder, Linda (author)
- Uppsala University,Uppsala universitet,Arbets- och miljömedicin,Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
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- Salihovic, Samira, Associate Senior Lecturer, 1985- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Univ Örebro, Sch Med Sci, Fac Med & Hlth, Örebro, Sweden.
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- Varotsis, Georgios (author)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden
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- Lind, P. Monica, 1957- (author)
- Uppsala University,Uppsala universitet,Arbets- och miljömedicin,Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
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- Elmståhl, Sölve (author)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups
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- Lind, Lars (author)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi,Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden
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- Elsevier, 2023
- 2023
- English.
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In: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 181
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Abstract
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- Background: Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals that have been linked to increased cholesterol levels and thus may have a role in the development of cardiovascular disease (CVD).Objectives: To investigate associations between PFAS exposure and incident CVD (a combined CVD end-point consisting of myocardial infarction, ischemic stroke, or heart failure) in two independent population-based cohorts in Sweden. In addition, we performed a meta-analysis also including results from previous studies.Methods: In 2,278 subjects aged 45-75 years from the EpiHealth study, the risk of incident CVD in relation to relative plasma levels of perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) was investigated. Associations between plasma levels of six PFAS and incident CVD were also examined in the PIVUS-study (n = 1,016, all aged 70 years). In addition, a meta-analysis was performed including three previous prospective studies, together with the results from the present study.Results: There were no overall statistically significant associations between levels of the different PFAS and incident CVD, neither in EpiHealth nor in PIVUS. However, there was a significant sex interaction for PFOS in EpiHealth (p = 0.008), and an inverse association could be seen only in men (Men, HR: 0.68, 95 % CI: 0.52, 0.89) (Women, HR: 1.13, 95 % CI: 0.82, 1.55). A meta-analysis of five independent studies regarding PFOA and incident CVD showed a risk ratio (RR) of 0.80 (CI: 0.66, 0.94) when high levels were compared to low levels.Conclusions: This longitudinal study using data from two population-based cohort studies in Sweden did not indicate any increased risk of incident CVD for moderately elevated PFAS levels. A meta-analysis of five independent cohort studies rather indicated a modest inverse association between PFOA levels and incident CVD, further supporting that increasing PFAS levels are not linked to an increased risk of CVD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Per-and polyfluoroalkyl substances (PFAS)
- Longitudinal
- Metabolomics
- Cardiovascular disease
- Subclinical markers
- Cardiovascular disease
- Longitudinal
- Metabolomics
- Per- and polyfluoroalkyl substances (PFAS)
- Subclinical markers
Publication and Content Type
- ref (subject category)
- art (subject category)
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