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Analgesic efficacy ...
Analgesic efficacy of sleep-promoting pharmacotherapy in patients with chronic pain : a systematic review and meta-analysis
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- Andersson, E. (författare)
- Lund Univ, Dept Clin Sci Lund, Lund, Sweden.,Lund University
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- Kander, Thomas (författare)
- Lund University,Lunds universitet,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups,Skåne University Hospital
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- Werner, Mads U. (författare)
- Copenhagen Univ Hosp, Multidisciplinary Pain Ctr, Neurosci Ctr, Copenhagen, Denmark.,Copenhagen University Hospital
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- Cho, J. H. (författare)
- Univ Calif Los Angeles UCLA, Dept Psychiat & Biobehav Sci, Cousins Ctr Psychoneuroimmunol, Semel Inst Neurosci & Human Behav,David Geffen Sc, Los Angeles, CA USA.,University of California, Los Angeles
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- Kosek, Eva (författare)
- Karolinska Institutet,Karolinska Institute,Uppsala universitet,Klinisk smärtforskning,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
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- Bjurstrom, M. F. (författare)
- Uppsala University,Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,University of California, Los Angeles,Skåne University Hospital
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Lund Univ, Dept Clin Sci Lund, Lund, Sweden Lund University (creator_code:org_t)
- Lippincott Williams & Wilkins, 2023
- 2023
- Engelska.
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Ingår i: Pain Rep. - : Lippincott Williams & Wilkins. - 2471-2531. ; 8:1, s. e1061-
- Relaterad länk:
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https://www.ncbi.nlm...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Dysregulation of sleep heightens pain sensitivity and may contribute to pain chronification. Interventions which consolidate and lengthen sleep have the potential to improve pain control. The main objective of this systematic review was to examine the effects of sleep-promoting pharmacotherapy on pain intensity in patients with chronic pain. Multiple electronic databases were searched from inception to January 2022 to identify relevant randomized controlled trials (RCTs). Two independent reviewers screened titles, abstracts, and full-text articles; extracted data; and assessed risk of bias for each included study. The GRADE approach was used to determine the strength of evidence. The search identified 624 articles. After full-text screening, 10 RCTs (n = 574 randomized participants) involving 3 pharmacologic interventions (melatonin, zopiclone, and eszopiclone) and 7 different chronic pain populations were included. Minimum clinically significant pain reduction >/=30% was reported in 4 studies. There is low-quality evidence (downgraded due to inconsistency and imprecision) that 2 to 8 weeks treatment with a sleep-promoting medication alone or in combination with an analgesic (6 trials, n = 397) decreases pain intensity compared with placebo or the same analgesic treatment alone (SMD -0.58 [95% confidence interval -1.00, -0.17], P = 0.006). Analyses of associations between changes in sleep and pain outcomes were only provided in 2 articles, with inconsistent findings. Notably, pain-relieving effects were most consistent in melatonin trials. Only 3 studies implemented polysomnography to obtain objective sleep measures. Low-quality evidence indicates that pharmacologic sleep promotion may decrease pain intensity in chronic pain populations. More research is needed to fully understand the influence of sleep-targeting interventions on pain control.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Nyckelord
- Analgesia
- Chronic pain
- Eszopiclone
- Insomnia
- Melatonin
- Pharmacotherapy
- Sleep
- Zopiclone
- Analgesia
- Chronic pain
- Eszopiclone
- Insomnia
- Melatonin
- Pharmacotherapy
- Sleep
- Zopiclone
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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