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Strict self-isolati...
Strict self-isolation did not protect Swedish cancer patients on active treatment from the risk of becoming seropositive for SARS-CoV-2
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- Ginman, Beatrice (author)
- Uppsala universitet,Cancerprecisionsmedicin
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- Pahnke, Simon (author)
- Uppsala universitet,Cancerprecisionsmedicin
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- Freyhult, Eva, 1979- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik,National Bioinformatics Infrastructure Sweden (NBIS)
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- Hoffman, Tove (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Kolstad, Linda (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Rönnberg, Bengt (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Lundkvist, Åke (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Hamberg Levedahl, Kerstin (author)
- Uppsala universitet,Vårdvetenskap
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- Enblad, Gunilla (author)
- Uppsala universitet,Cancerimmunterapi
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- Glimelius, Ingrid, 1975- (author)
- Karolinska Institutet,Uppsala universitet,Cancerprecisionsmedicin
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(creator_code:org_t)
- Taylor & Francis, 2023
- 2023
- English.
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In: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 62:12, s. 1707-1715
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Abstract
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- BackgroundSwedish recommendations to reduce the risk of COVID-19 relied on each citizen’s own sense of responsibility rather than mandatory lockdowns. We studied how COVID-19-related self-isolation and anxiety correlated to SARS-CoV-2 seropositivity and PCR-positivity in patients with active cancer treatment.MethodsIn a longitudinal cohort study at Uppsala University Hospital patients and cancer personnel were included between April 1st 2020 to August 1st 2020. Serological testing for SARS-CoV-2 was done every 8–12-weeks until 30 March 2021. Patients completed a survey at inclusion regarding self-reported COVID-19-related anxiety and self-isolation.ResultsA total of 622 patients [n = 475 with solid malignancies (SM), n = 147 with haematological malignancies (HM)], and 358 healthcare personnel were included. The seropositivity rate was lower for patients than for personnel; 10.5% for SM patients, 6.8% for HM patients, and 16.2% for personnel (p = 0.005). Strict adherence to self-isolation guidelines was reported by 54% of patients but was not associated with a lower risk of becoming seropositive [OR = 1.4 (0.8–2.5), p = 0.2]. High anxiety was expressed by 32% of patients, more often by SM patients than HM patients (34% vs 25% [OR = 1.6 (1.1–2.5, p = 0.03)]). Female gender [OR = 3.5 (2.4–5.2), p < 0.001] and being born outside of Europe [OR = 2.9 (1.4–6.4), p = 0.007] were both associated with high anxiety. Patients reporting high anxiety became seropositive to a similar degree as those with low anxiety [OR = 0.7 (0.3–1.2), p = 0.2]. HM patients with PCR-positive COVID-19 were more likely than SM patients to require oxygen therapy, including non-invasive ventilation/intubation (69% vs. 26%, p = 0.005).ConclusionFor Swedish patients on active cancer treatment, high self-assessed COVID-19-related anxiety or strict adherence to self-isolation guidelines were not associated with a lower risk of COVID-19. Patients with HM were less likely to develop serological antibody response after COVID-19 and were more likely to require advanced hospital care, but expressed less COVID-19-related anxiety than patients with SM.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Cancer
- COVID-19
- seropositivity
- PCR-positivity
- self-isolation
- anxiety
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ginman, Beatrice
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Pahnke, Simon
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Freyhult, Eva, 1 ...
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Hoffman, Tove
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Kolstad, Linda
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Rönnberg, Bengt
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Lundkvist, Åke
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Hamberg Levedahl ...
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Enblad, Gunilla
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Glimelius, Ingri ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Acta Oncologica
- By the university
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Uppsala University
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Karolinska Institutet