Sökning: id:"swepub:oai:DiVA.org:uu-522927" >
Nerve Tracing in Ju...
Nerve Tracing in Juvenile Rats : A Feasible Model for the Study of Brachial Plexus Birth Palsy and Cocontractions?
-
- Jonsson, Krister (författare)
- Karolinska Inst Dept Clin Sci & Educ, Dept Handsurgery Sodersjukhuset, Sodersjukhuset, Dept Orthoped Surg, Stockholm, Sweden.;Karolinska Inst, Sodersjukhuset, Dept Handsurgery Sodersjukhuset, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden.
-
- Hultgren, Tomas (författare)
- Karolinska Inst Dept Clin Sci & Educ, Dept Handsurgery Sodersjukhuset, Sodersjukhuset, Dept Orthoped Surg, Stockholm, Sweden.
-
- Risling, Marten (författare)
- Karolinska Inst, Expt Traumatol Unit, Dept Neurosci, Solna, Sweden.
-
visa fler...
-
- Sköld, Mattias K. (författare)
- Uppsala universitet,Neurokirurgi,Karolinska Inst, Expt Traumatol Unit, Dept Neurosci, Solna, Sweden.;Uppsala Univ, Dept Med Sci, Sect Neurosurg, Uppsala, Sweden.
-
visa färre...
-
Karolinska Inst Dept Clin Sci & Educ, Dept Handsurgery Sodersjukhuset, Sodersjukhuset, Dept Orthoped Surg, Stockholm, Sweden;Karolinska Inst, Sodersjukhuset, Dept Handsurgery Sodersjukhuset, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden. Karolinska Inst Dept Clin Sci & Educ, Dept Handsurgery Sodersjukhuset, Sodersjukhuset, Dept Orthoped Surg, Stockholm, Sweden. (creator_code:org_t)
- THIEME MEDICAL PUBL INC, 2024
- 2024
- Engelska.
-
Ingår i: Journal of Brachial Plexus and Peripheral Nerve Injury. - : THIEME MEDICAL PUBL INC. - 1749-7221. ; 19:01, s. e6-e12
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Brachial plexus birth injuries cause diminished motor function in the upper extremity. The most common sequel is internal rotation contracture. A number of these patients also suffer from cocontractions, preventing the use of an otherwise good passive range of motion in the shoulder. One theory behind the co-contracture problem is that injured nerve fibers grow into distal support tissue not corresponding to the proximal support tissue, resulting in reinnervation of the wrong muscle groups. To further elucidate this hypothesis, we used rat neonates to investigate a possible model for the study of cocontractions in brachial plexus birth injuries. Five-day-old rats were subjected to a crush injury to the C5-C6 roots. After a healing period of 4 weeks, the infraspinatus muscle was injected with Fluoro-Gold. A week later, the animals were perfused and spinal cords harvested and sectioned. Differences in the uptake of Fluoro-Gold and NeuN positive cells of between sides of the spinal cord were recorded. We found a larger amount of Fluoro-Gold positive cells on the uninjured side, while the injured side had positive cells dispersed over a longer area in the craniocaudal direction. Our findings indicate that the method can be used to trace Fluoro-Gold from muscle through a neuroma. Our results also indicate that a neuroma in continuity somewhat prevents the correct connection from being established between the motor neuron pool in the spinal cord and target muscle and that some neurons succumb to a crushing injury. We also present future research ideas.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- brachial plexus birth injury
- cocontraction
- Fluoro-Gold
- rat
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas