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SpotLight Proteomic...
SpotLight Proteomics Identifies Variable Sequences of Blood Antibodies Specific Against Deamidated Human Serum Albumin
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- Wang, Jijing (författare)
- Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
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- Lundström, Susanna L. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
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- Lu, Weiqi (författare)
- Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.;Xi An Jiao Tong Univ, Dept Ophthalmol, Affiliated Hosp 1, Xian, Peoples R China.
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- Huang, Yiqi (författare)
- Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.;Tech Univ Munich, Inst Virol, Sch Med, Munich, Germany.
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- Rodin, Sergey (författare)
- Uppsala universitet,Thoraxkirurgi,Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
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- Zubarev, Roman A. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Molecular & Cellular Proteomics. - : Elsevier. - 1535-9476 .- 1535-9484. ; 22:7
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Spontaneous deamidation of asparaginyl residues in proteins, if not repaired or cleared, can set in motion a cascade that leads to deteriorated health. Previously, we have discovered that deamidated human serum albumin (HSA) is elevated in the blood of patients with Alzheimer's disease and other neurodegenerative diseases, while the level of endogenous antibodies against deamidated HSA is significantly diminished, creating an imbalance between the risk factor and the defense against it. Endogenous antibodies against deamidated proteins are still unexplored. In the current study, we employed the SpotLight proteomics approach to identify novel amino acid sequences in antibodies specific to deamidated HSA. The results provide new insights into the clearance mechanism of deamidated proteins, a possible avenue for prevention of neurodegeneration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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