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Anti-histone and an...
Anti-histone and anti-nucleosome rather than anti-dsDNA antibodies associate with IFN-induced biomarkers in Sudanese and Swedish Systemic Lupus Erythematosus patients.
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- Elbagir, Sahwa (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden
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- Mohammed, NasrEldeen A (författare)
- Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.,Al Neelain Univ, Sudan
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- Oke, Vilija (författare)
- Karolinska Institutet
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi,Uppsala Univ, Sweden
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- Nilsson, Jan (författare)
- Department of Experimental Medical Science, Lund University, Lund, Sweden.,Lund Univ, Sweden
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- Elshafie, Amir (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Region Östergötland, Klinisk immunologi och transfusionsmedicin,Uppsala Univ, Sweden
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- Elagib, Elnour M (författare)
- Rheumatology unit, Alribat University Hospital, Khartoum, Sudan.,Mil Hosp, Sudan
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- Nur, Musa A M (författare)
- Rheumatology unit, Alribat University Hospital, Khartoum, Sudan.,Alribat Univ Hosp, Sudan
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- Gunnarsson, Iva (författare)
- Karolinska Institutet
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- Svenungsson, Elisabet (författare)
- Division of Rheumatology, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.,Karolinska Inst, Sweden
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- Rönnelid, Johan (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Rheumatology. - : OXFORD UNIV PRESS. - 1462-0324 .- 1462-0332.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: In SLE, anti-dsDNA can co-occur with autoantibodies against other chromatin components, like histones and nucleosomes. These antibodies induce type-1 interferon production, a hallmark of SLE. We measured antinuclear antibody (ANA) sub-specificities and investigated their associations to inflammatory biomarkers including interferon-regulated chemokines.METHODS: We included 93 Sudanese and 480 Swedish SLE patients and matched controls (N = 104 + 192). Autoantibodies targeting ANA-subspecificites: dsDNA, Sm, Sm/U1RNPcomplex, U1RNP, SSA/Ro52, SSA/Ro60, SSB/La, ribosomal P, PCNA and histones were quantified in all subjects, anti-nucleosome only in the Swedish patients, with a bead-based multiplex immunoassay. Levels of 72 plasma biomarkers were determined with Proximity Extension Assay technique or ELISA.RESULTS: Among Sudanese patients, the investigated antibodies significantly associated with 9/72 biomarkers. Anti-histone antibodies showed the strongest positive correlations with MCP-3 and S100A12 as well as with interferon I-inducible factors MCP-1 and CXCL10. Anti-dsDNA antibodies associated with CXCL10 and S100A12, but in multivariate analyses, unlike anti-histone, associations lost significance.Among Swedish patients, MCP-1, CXCL10, SA100A12 also demonstrated stronger associations to anti-histone and anti-nucleosome antibodies, compared with anti-dsDNA and other ANA sub-specificities. In multiple regression models, anti-histone/nucleosome retained the strongest associations. When excluding anti-histone or anti-nucleosome positive patients, the associations between MCP-1/CXCL10 and anti-dsDNA were lost. In contrast, when excluding anti-dsDNA positive patients, associations with anti-histone and anti-nucleosome remained significant.CONCLUSION: In two cohorts of different ethnical origin, autoantibodies targeting chromatin correlate stronger with IFN-induced inflammatory biomarkers than anti-dsDNA or other ANA sub-specificities. Our results suggest that anti-histone/nucleosome autoantibodies may be main drivers of type-1 interferon activity in SLE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Africa
- Anti-chromatin antibodies
- SLE
- anti-dsDNA
- interferon
- proteome analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Elbagir, Sahwa
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Mohammed, NasrEl ...
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Oke, Vilija
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Larsson, Anders
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Nilsson, Jan
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Elshafie, Amir
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visa fler...
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Elagib, Elnour M
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Nur, Musa A M
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Gunnarsson, Iva
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Svenungsson, Eli ...
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Rönnelid, Johan
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