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Herpes Simplex Vira...
Herpes Simplex Viral Infection Doubles the Risk of Dementia in a Contemporary Cohort of Older Adults : A Prospective Study
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- Vestin, Erika (författare)
- Uppsala universitet,Klinisk geriatrik,Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden
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- Boström, Gustaf (författare)
- Uppsala universitet,Klinisk geriatrik,Centrum för klinisk forskning, Västerås,Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden; Centre for Clinical Research, Västmanland and County Hospital, Uppsala University, Västerås, Sweden
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- Olsson, Jan (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Univ, Dept Clin Microbiol, Umeå, Sweden.
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- Elgh, Fredrik, 1957- (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Univ, Dept Clin Microbiol, Umeå, Sweden.
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Sciences, Acute and Internal Medicine, Uppsala University, Uppsala, Sweden
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- Kilander, Lena (författare)
- Uppsala universitet,Klinisk geriatrik,Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden
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- Lövheim, Hugo, 1981- (författare)
- Umeå universitet,Geriatrik,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, Umeå, Sweden.
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- Weidung, Bodil (författare)
- Uppsala universitet,Klinisk geriatrik,Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- IOS Press, 2024
- 2024
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 97:4, s. 1841-1850
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Evidence indicates that herpes simplex virus (HSV) participates in the pathogenesis of Alzheimer's disease (AD). Objective: We investigated AD and dementia risks according to the presence of herpesvirus antibodies in relation to antiherpesvirus treatment and potential APOE epsilon 4 carriership interaction. Methods: This studywas conducted with 1002 dementia-free 70-year-olds living in Sweden in 2001-2005 who were followed for 15 years. Serum samples were analyzed to detect anti-HSV and anti-HSV-1 immunoglobulin (Ig) G, anti-cytomegalovirus (CMV) IgG, anti-HSV IgM, and anti-HSV and anti-CMV IgG levels. Diagnoses and drug prescriptions were collected from medical records. Cox proportional-hazards regression models were applied. Results: CumulativeADand all-cause dementia incidences were 4% and 7%, respectively. Eighty-two percent of participants were anti-HSV IgG carriers, of whom 6% received anti-herpesvirus treatment. Anti-HSV IgG was associated with a more than doubled dementia risk (fully adjusted hazard ratio = 2.26, p = 0.031). No significant association was found with AD, but the hazard ratio was of the same magnitude as for dementia. Anti-HSV IgM and anti-CMV IgG prevalence, anti-herpesvirus treatment, and anti-HSV and -CMV IgG levels were not associated with AD or dementia, nor were interactions between anti-HSV IgG and APOE epsilon 4 or anti-CMV IgG. Similar results were obtained for HSV-1. Conclusions: HSV (but not CMV) infection may be indicative of doubled dementia risk. The low AD incidence in this cohort may have impaired the statistical power to detect associations with AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- Aged 80 and over
- Alzheimer disease
- apolipoprotein E
- cognitive disorder
- cohort study
- cytomegalovirus
- dementia
- Herpes simplex
- human herpesvirus 1
- neurocognitive disorder
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Vestin, Erika
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Boström, Gustaf
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Olsson, Jan
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Elgh, Fredrik, 1 ...
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Lind, Lars
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Kilander, Lena
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Lövheim, Hugo, 1 ...
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Weidung, Bodil
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Geriatrik
- Artiklar i publikationen
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Journal of Alzhe ...
- Av lärosätet
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Uppsala universitet
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Umeå universitet