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Gut microbiota dist...
Gut microbiota disturbances in hospitalized older adults with malnutrition and clinical outcomes
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- Muñoz-Fernandez, Shirley S. (författare)
- Univ Sao Paulo, Sch Publ Hlth, Nutr Dept, Sao Paulo, SP, Brazil.
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- Garcez, Flavia B. (författare)
- Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Serv Geriatria,Lab Invest Med Envelhecimento LIM, Sao Paulo, SP, Brazil.;Univ Fed Sergipe, Hosp Univ, Dept Med, Aracaju, Sergipe, Brazil.
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- Alencar, Julio C. G. (författare)
- Univ Sao Paulo, Fac Med, Dept Clin Med, Disciplina Emergencias Clin, Sao Paulo, SP, Brazil.
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- Bastos, Amália A. (författare)
- Univ Sao Paulo, Sch Publ Hlth, Nutr Dept, Sao Paulo, SP, Brazil.
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- Morley, John E. (författare)
- St Louis Univ, Sch Med, Div Geriatr Med, St Louis, MO USA.
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- Cederholm, Tommy (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Karolinska Univ Hosp, Stockholm, Sweden
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- Aprahamian, Ivan (författare)
- Jundiai Med Sch, Dept Internal Med, Div Geriatr, Grp Invest Multimorbid & Mental Hlth Aging GIMMA, Jundiai, SP, Brazil.
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- de Souza, Heraldo P. (författare)
- Univ Sao Paulo, Fac Med, Dept Clin Med, Disciplina Emergencias Clin, Sao Paulo, SP, Brazil.
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- Avelino-Silva, Thiago J. (författare)
- Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Serv Geriatria,Lab Invest Med Envelhecimento LIM, Sao Paulo, SP, Brazil.
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- Bindels, Laure B. (författare)
- Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, Brussels, Belgium.
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- Ribeiro, Sandra M. L. (författare)
- Univ Sao Paulo, Sch Publ Hlth, Nutr Dept, Sao Paulo, SP, Brazil.;Univ Sao Paulo, Sch Arts Sci & Humanity, Sao Paulo, SP, Brazil.
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Univ Sao Paulo, Sch Publ Hlth, Nutr Dept, Sao Paulo, SP, Brazil Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Serv Geriatria,Lab Invest Med Envelhecimento LIM, Sao Paulo, SP, Brazil.;Univ Fed Sergipe, Hosp Univ, Dept Med, Aracaju, Sergipe, Brazil. (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Nutrition. - : Elsevier. - 0899-9007 .- 1873-1244. ; 122
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- ObjectiveMalnutrition is one of the most threatening conditions in geriatric populations. The gut microbiota has an important role in the host's metabolic and muscular health: however, its interplay with disease-related malnutrition is not well understood. We aimed to identify the association of malnutrition with the gut microbiota and predict clinical outcomes in hospitalized acutely ill older adults.MethodsWe performed a secondary longitudinal analysis in 108 geriatric patients from a prospective cohort evaluated at admission and 72 h of hospitalization. We collected clinical, demographic, nutritional, and 16S rRNA gene-sequenced gut microbiota data. Microbiota diversity, overall composition, and differential abundance were calculated and compared between patients with and without malnutrition. Microbiota features associated with malnutrition were used to predict clinical outcomes.ResultsPatients with malnutrition (51%) had a different microbiota composition compared to those who were well-nourished during hospitalization (ANOSIM R = 0.079, P = 0.003). Patients with severe malnutrition showed poorer α-diversity at admission (Shannon P = 0.012, Simpson P = 0.018) and follow-up (Shannon P = 0.023, Chao1 P = 0.008). Differential abundance of Lachnospiraceae NK4A136 group, Subdoligranulum, and Faecalibacterium prausnitzii were significantly lower and inversely associated with malnutrition, while Corynebacterium, Ruminococcaceae Incertae Sedis, and Fusobacterium were significantly increased and positively associated with malnutrition. Corynebacterium, Ruminococcaceae Incertae Sedis, and the overall composition were important predictors of critical care in patients with malnutrition during hospitalization.ConclusionOlder adults with malnutrition, especially in a severe stage, may be subject to substantial gut microbial disturbances during hospitalization. The gut microbiota profile of patients with malnutrition might help us to predict worse clinical outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- Acute disease
- Critical care
- Gut microbiota
- GLIM criteria
- Malnutrition
- Older adults
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Muñoz-Fernandez, ...
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Garcez, Flavia B ...
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Alencar, Julio C ...
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Bastos, Amália A ...
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Morley, John E.
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Cederholm, Tommy
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visa fler...
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Aprahamian, Ivan
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de Souza, Herald ...
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Avelino-Silva, T ...
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Bindels, Laure B ...
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Ribeiro, Sandra ...
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- MEDICIN OCH HÄLSOVETENSKAP
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- MEDICIN OCH HÄLSOVETENSKAP
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Nutrition
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Uppsala universitet