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The Swedish initiat...
The Swedish initiative for the study of Primary sclerosing cholangitis (SUPRIM)
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- Cornillet, Martin (författare)
- Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.
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- Villard, Christina (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Transplantat Surg, Stockholm, Sweden.
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- Rorsman, Fredrik, Docent, 1960- (författare)
- Akadem Univ Hosp, Dept Obstet & Gynaecol, Uppsala, Sweden
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- Molinaro, Antonio (författare)
- Sahlgrens Univ Hosp, Dept Orthopaed, SE-41345 Gothenburg, Sweden.
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- Nilsson, Emma (författare)
- Skane Univ Hosp, Gastroenterol Clin, Scania, Sweden.
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- Kechagias, Stergios (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken,Linköping Univ, Dept Hlth Med & Caring Sci, Linköping, Sweden.
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- von Seth, Erik (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Upper Abdominal Dis, Stockholm, Sweden.
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- Bergquist, Annika (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Upper Abdominal Dis, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: eClinicalMedicine. - : Elsevier. - 2589-5370. ; 70
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundDespite more than 50 years of research and parallel improvements in hepatology and oncology, there is still today neither a treatment to prevent disease progression in primary sclerosing cholangitis (PSC), nor reliable early diagnostic tools for the associated hepatobiliary cancers. Importantly, the limited understanding of the underlying biological mechanisms in PSC and its natural history not only affects the identification of new drug targets but implies a lack of surrogate markers that hampers the design of clinical trials and the evaluation of drug efficacy. The lack of easy access to large representative well-characterised prospective resources is an important contributing factor to the current situation.MethodsWe here present the SUPRIM cohort, a national multicentre prospective longitudinal study of unselected PSC patients capturing the representative diversity of PSC phenotypes. We describe the 10-year effort of inclusion and follow-up, an intermediate analysis report including original results, and the associated research resource. All included patients gave written informed consent (recruitment: November 2011–April 2016).FindingsOut of 512 included patients, 452 patients completed the five-year follow-up without endpoint outcomes. Liver transplantation was performed in 54 patients (10%) and hepatobiliary malignancy was diagnosed in 15 patients (3%). We draw a comprehensive landscape of the multidimensional clinical and biological heterogeneity of PSC illustrating the diversity of PSC phenotypes. Performances of available predictive scores are compared and perspectives on the continuation of the SUPRIM cohort are provided.InterpretationWe envision the SUPRIM cohort as an open-access collaborative resource to accelerate the generation of new knowledge and independent validations of promising ones with the aim to uncover reliable diagnostics, prognostic tools, surrogate markers, and new treatment targets by 2040.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Primary sclerosing cholangitis
- Inflammatory bowel disease
- Liver transplantation
- Phenotype
- Outcome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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