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Influence of the sp...
Influence of the specific T cell response on seroconversion after measles vaccination in autologous bone marrow transplant patients
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- Pauksen, Karlis (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion
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Linde, A. (författare)
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- Lönnerholm, Gudmar (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Lönnerholm
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- Ljungman, P. (författare)
- Karolinska Institutet
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- Sjölin, Jan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion
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(creator_code:org_t)
- 1996
- 1996
- Engelska.
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Ingår i: Bone Marrow Transplantation. - 0268-3369 .- 1476-5365. ; 18:5, s. 969-973
- Relaterad länk:
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Six patients who were seronegative to measles after autologous bone marrow transplantation (ABMT) were vaccinated with a live attenuated measles vaccine. The specific T helper cell response was studied by measuring lymphocyte proliferation induced by measles antigen and B cell response by measles specific IgG by ELISA. Blood samples were drawn before, at 1-3 months, and at 1 year after vaccination. It was found that a pre-existing T cell response correlated with an impaired B cell response 1 year after vaccination (r = 0.83, P = 0.04), whereas no correlation was found between IgG titers before vaccination and IgG titer increase, or T cell response after vaccination. Furthermore, there was a transient negative correlation between the T cell response at 1-3 months after vaccination and the T cell response before vaccination (r = -0.90, P = 0.04) that became positive at 1 year after vaccination (r = 0.90, P = 0.02). In conclusion, in patients seronegative to measles who were revaccinated with measles vaccine after ABMT, a pre-existing T cell response correlated with an impaired B cell response, while pre-existing low-level IgG antibodies had no significant influence on the IgG titer rise. A sustained T cell response to measles antigen before vaccination may thus be one possible explanation for measles vaccine failure in ABMT patients.
Nyckelord
- MEDICINE
- MEDICIN
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- ref (ämneskategori)
- art (ämneskategori)
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