The 5-HT1A receptor antagonist (S)-UH-301 augments the increase in extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram

• In a recent study, utilizing single cell recording techniques, we have shown that administration of 5-HT1A receptor antagonists, e.g. (S)-UH-301, to rats concomitantly treated, acute or chronically, with the selective serotonin reuptake inhibitor (SSRI)

Nyckelord

antidepressant; citalopram; frontal cortex; microdialysis; serotonin; 5-HT1A receptor antagonist; (S)-UH-301; DORSAL RAPHE; ANTIDEPRESSANT TREATMENTS; BRAIN MICRODIALYSIS; SEROTONIN FUNCTION; UPTAKE INHIBITOR; RAT HIPPOCAMPUS; INVIVO; 5-HYDROXYTRYPTAMIN

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