Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

• Beta-secretase (BACE) and glycogen synthase kinase (GSK 3) are two enzymes thought to play a role in Alzheimer's disease. We extracted mRNA from 90 Alzheimer and 81 control brains. Levels of mRNA were quantified for BACE and GSK 3 with TaqMan real-time RT-PCR. We found no change in the Alzheimer's disease brains relative to controls for either the BACE or the GSK 3alpha mRNA levels.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)

Nyckelord

Alzheimer Disease/*enzymology/genetics/metabolism

Amyloid beta-Protein Precursor/analysis/genetics

Comparative Study

Endopeptidases/genetics/*metabolism

Female

Glial Fibrillary Acidic Protein/analysis/genetics

Glycogen Synthase Kinase 3/genetics/*metabolism

Humans

Male

Microtubule-Associated Proteins/analysis/genetics

Phosphopyruvate Hydratase/analysis/genetics

RNA; Messenger/analysis/biosynthesis

Reverse Transcriptase Polymerase Chain Reaction/methods

Sex Characteristics

Neurobiology

Neurobiologi

Genetics

Genetik

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)