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Assessment of T1 an...
Assessment of T1 and T2* effects in vivo and ex vivo using iron oxide nanoparticles in steady state : dependence on blood volume and water exchange
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- Bjørnerud, Atle (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Radiologi,Ahlström
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- Johansson, Lars O. (author)
- Uppsala universitet,Enheten för radiologi,Ahlström
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- Briley-Sæbø, Karen (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Radiologi,Ahlström
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- Ahlström, Håkan K. (author)
- Uppsala universitet,Enheten för radiologi,Ahlström
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(creator_code:org_t)
- 2002-02-20
- 2002
- English.
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In: Magnetic Resonance in Medicine. - : Wiley. - 0740-3194 .- 1522-2594. ; 47:3, s. 461-471
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Abstract
Subject headings
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- Accurate knowledge of the relationship between contrast agent concentration and tissue relaxation is a critical requirement for quantitative assessment of tissue perfusion using contrast-enhanced MRI. In the present study, using a pig model, the relationship between steady-state blood concentration levels of an iron oxide nanoparticle with a hydrated diameter of 12 nm (NC100150 Injection) and changes in the transverse and longitudinal relaxation rates (1/T2* and 1/T1, respectively) in blood, muscle, and renal cortex was investigated at 1.5 T. Ex vivo measurements of 1/T2* and 1/T1 were additionally performed in whole pig blood spiked with different concentrations of the iron oxide nanoparticle. In renal cortex and muscle, 1/T2* increased linearly with contrast agent concentration with slopes of 101 +/-22 s(-1)mM(-1) and 6.5 +/-0.9 s(-1)mM(-1) (mean +/- SD), respectively. In blood, 1/T2* increased as a quadratic function of contrast agent concentration, with different quadratic terms in the ex vivo vs. the in vivo experiments. In vivo, 1/T1 in blood increased linearly with contrast agent concentration, with a slope (T1-relaxivity) of 13.9 +/- 0.9 s(-1)mM(-1). The achievable increase in 1/T1 in renal cortex and muscle was limited by the rate of water exchange between the intra- and extravascular compartments and the 1/T1-curves were well described by a two-compartment water exchange limited relaxation model.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Animals
- Blood Volume
- Body Water/metabolism
- Contrast Media/*pharmacokinetics
- Image Processing; Computer-Assisted
- Iron/*pharmacokinetics
- Kidney Cortex/*anatomy & histology
- Magnetic Resonance Imaging/*methods
- Muscles/*anatomy & histology
- Nanotechnology
- Oxides/*pharmacokinetics
- Particle Size
- Research Support; Non-U.S. Gov't
- Swine
Publication and Content Type
- ref (subject category)
- art (subject category)
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