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Aldosterone synthas...
Aldosterone synthase (CYP11B2) -344 C/T polymorphism is related to antihypertensive response : result from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA) trial
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- Kurland, Lisa (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden, Department of Internal Medicine, Uppsala University Hospital, SE-751 85 Uppsala, Sweden
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- Melhus, Håkan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Melhus, H.åkan, Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
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- Karlsson, Julia (författare)
- Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
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- Kahan, Thomas (författare)
- Division of Internal Medicine, Karolinska Institute, Danderyd Hospital, Danderyd, Sweden
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- Malmqvist, Karin (författare)
- Division of Internal Medicine, Karolinska Institute, Danderyd Hospital, Danderyd, Sweden
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- Öhman, Peter (författare)
- Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet
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- Nyström, Fredrik (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Internmedicin,Endokrin- och magtarmmedicinska kliniken US
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- Hägg, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Hägg, A., Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
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- Lind, Lars (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akut- och internmedicin,Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier, 2002
- 2002
- Engelska.
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Ingår i: American Journal of Hypertension. - : Elsevier. - 0895-7061 .- 1941-7225. ; 15:5, s. 389-93
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Our aim was to determine whether the aldosterone synthase (CYP11B2) -344 C/T polymorphism was associated with the blood pressure (BP)-lowering response to antihypertensive treatment. METHODS: Patients with mild-to-moderate primary hypertension and left ventricular hypertrophy were randomized in a double-blind study to receive treatment with either the angiotensin II type 1 (AT1) receptor antagonist irbesartan (n = 43), or the beta1-adrenergic receptor blocker atenolol (n = 43). The aldosterone synthase (CYP11B2) -344 C/T polymorphism was analyzed using solid-phase minisequencing and related to BP reduction after 3 months treatment. Serum aldosterone levels were measured. RESULTS: After 3 months treatment the mean reductions in BP were similar for both treatment groups. When assessing the systolic BP reduction in the irbesartan group, patients with the TT variant had a more pronounced reduction (-21 +/- 19 SD mm Hg, n = 17) than both the TC (-14 +/- 18 mm Hg, n= 18) and CC (0 +/- 17 mm Hg, n = 8) genotypes (P = .04). There was no association between this polymorphism and the diastolic BP response. The -344 C/T polymorphism was not associated with the BP response to atenolol. Nor was it related to the baseline serum aldosterone level. CONCLUSIONS: The aldosterone synthase -344 C/T polymorphism was related to the BP-lowering response in hypertensive patients treated with the AT1-receptor antagonist irbesartan.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Adrenergic beta-Antagonists/*therapeutic use
- Aldosterone/blood
- Aldosterone Synthase/*genetics
- Antihypertensive Agents/*therapeutic use
- Atenolol/*therapeutic use
- Base Sequence/genetics
- Biphenyl Compounds/*therapeutic use
- Blood Pressure
- Comparative Study
- Cytosine
- Double-Blind Method
- Female
- Humans
- Hypertension/blood/*drug therapy/*genetics/physiopathology
- Hypertrophy; Left Ventricular/drug therapy
- Male
- Middle Aged
- Polymorphism; Genetic
- Receptor; Angiotensin; Type 1
- Receptors; Angiotensin/antagonists & inhibitors
- Research Support; Non-U.S. Gov't
- Tetrazoles/*therapeutic use
- Thymine
- Treatment Outcome
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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