Increased serum cyststin C is associated with increased mortality in elderly men

• Renal dysfunction measured by serum creatinine is associated with increased cardiovascular morbidity and mortality. Plasma cystatin C has been shown in several studies to be superior to plasma creatinine for the estimation of glomerular filtration rate (GFR). The aim of the present study was to investigate the relationship between cystatin C and mortality in elderly men. Serum cystatin C was analyzed by nephelometry in a group of 77-year-old men (n=792) and correlated cystatin C levels with mortality during a follow-up period of 1-4 years. The cystatin C values were significantly correlated with overall mortality (p=0.013). Mortality was three times higher in the highest cystatin C quintile in relation to the lowest quintile.

Nyckelord

Aged

Biological Markers/*blood

Cohort Studies

Cystatins/*blood

Glomerular Filtration Rate

Humans

Kidney Failure; Chronic/*blood/*mortality

Male

Nephelometry and Turbidimetry

Prognosis

Risk Factors

MEDICINE

MEDICIN

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)