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Changes of cartilag...
Changes of cartilage and bone markers after intra- articular glucocorticoid treatment with and without postinjection rest in patients with rheumatoid arthritis
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- Weitoft, Tomas (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Institutionen för medicinska vetenskaper
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- Larsson, Anders (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Biokemisk struktur och funktion
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- Saxne, Tore (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Rönnblom, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- BMJ, 2005
- 2005
- English.
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In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 64:12, s. 1750-1753
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Abstract
Subject headings
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- BACKGROUND: Joint immobilisation improves the therapeutic effect of intra-articular glucocorticoid injection for knee synovitis. This may be due to retarded steroid resorption by immobilisation, a procedure that also could influence cartilage and bone metabolism. OBJECTIVE: To evaluate changes in cartilage and bone turnover after intra-articular glucocorticoid treatment for knee synovitis with and without postinjection rest. METHODS: 20 patients with rheumatoid arthritis and knee synovitis were randomised to 24 hour bed rest or to normal activity after intra-articular glucocorticoid treatment. Serum and urine markers of cartilage and bone turnover were studied for two weeks. Cartilage oligomeric matrix protein (COMP) was used as a marker of cartilage turnover, osteocalcin as marker of bone formation, and deoxipyridinoline (DPD) as marker of bone resorption. RESULTS: After the glucocorticoid injection COMP levels decreased in both groups (p<0.001), but significantly more in resting patients. Serum osteocalcin levels decreased significantly (p<0.001) without any difference between the groups. DPD was unchanged in both groups. CONCLUSIONS: Intra-articular glucocorticoid treatment for knee synovitis reduced serum COMP, which suggests that such treatment may have a cartilage protective effect. The slightly larger decrease of serum COMP in the resting group may reflect a lower clearance of COMP from the joint cavity. Serum osteocalcin was temporarily reduced, indicating a reversible suppression of bone formation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Animals
- Biological Markers
- Blood-Brain Barrier/*physiopathology
- Endotoxemia/*blood/physiopathology
- Female
- Hemoglobins/analysis
- Male
- Nerve Growth Factors/*blood
- S100 Proteins/*blood
- Shock; Septic/*blood/physiopathology
- Swine
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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