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Women with palmoplantar pustulosis have disturbed calcium homeostasis and a high prevalence of diabetes mellitus and psychiatric disorders : a case-control study

Hagforsen, Eva (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
Michaëlsson, Karl (författare)
Uppsala universitet,Ortopedi
Lundgren, Ewa (författare)
Uppsala universitet,Institutionen för kirurgiska vetenskaper
visa fler...
Olofsson, Helena (författare)
Petersson, Axel (författare)
Lagumdzija, Alena (författare)
Hedstrand, Håkan (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
Michaelsson, Gerd (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
visa färre...
 (creator_code:org_t)
Medical Journals Sweden AB, 2005
2005
Engelska.
Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 85:3, s. 225-232
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Palmoplantar pustulosis is characterized by pustule formation in the acrosyringium. Nearly 50% of palmoplantar pustulosis sera produce immunofluorescence of the palmar papillary endothelium from healthy subjects, but also of the endothelium of normal parathyroid gland. With a case-control design the levels of calcium and parathyroid hormone in serum were measured in 60 women with palmoplantar pustulosis and 154 randomly selected population-based control women. One-third of the controls had been smokers, whereas 95% of the cases were or had been smokers. Mean age-adjusted serum calcium was increased in the patients compared with the controls (2.43 vs 2.36 mmol/l; p<0.0001), whereas the parathyroid hormone concentration was suppressed (23.2 vs 31.1 ng/l; p<0.0001). The plasma levels of parathyroid hormone-related protein were normal in patients but there was a strong expression of this protein in the acrosyringium both in palmoplantar pustulosis and control skin. As even a marginal elevation of serum calcium is associated with an increased risk for diabetes, cardiovascular disease and psychiatric disease, we analysed the risk for these disorders in palmoplantar pustulosis patients compared with that in the control group. Both diabetes mellitus and psychiatric disorders were associated with palmoplantar pustulosis with an odds ratio of 8.7 (95% CI 3.3-22.8) and 5.6 (95% CI 2.2-14.4), respectively. Palmoplantar pustulosis is a complex disease with an increased risk for several non-dermatological disorders. The role of the mildly increased serum calcium for the high risk for diabetes and depression deserves to be studied.

Nyckelord

Adult
Aged
Calcium/*blood
Case-Control Studies
Diabetes Mellitus
Female
Homeostasis
Humans
Mental Disorders/*complications
Middle Aged
Parathyroid Hormone-Related Protein/blood/*metabolism
Prevalence
Psoriasis/blood/complications/epidemiology/*metabolism
Research Support; Non-U.S. Gov't
Sweden/epidemiology
MEDICINE
MEDICIN

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