Syntheses of [21-C-11] and (21-C-13)Progesterone

• [21-C-11]Progesterone was synthesised via the cross-coupling 17 beta-carboxylic acid chloride-4-androsten-3-one with lithium [C-11]methyl(2-thienyl)cuprate (LiCN). The title compound was obtained in 30-35% decay corrected radiochemical yield, based on [C

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[21-C-11]Progesterone; [C-11]methyl(2-thienyl)cuprate; cross-coupling; C-11; (21-C-13)progesterone; POSITRON EMISSION TOMOGRAPHY; BREAST-CANCER; PROGESTERONE RECEPTORS; IMAGING AGENTS; TUMORS; 21-<F-18>FLUORO-16-ALPHA-ETHYL-19-NORPROGESTERONE; RADIOTRAC

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