Retinoic acid receptor retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation

• The receptor for 9-cis-retinoic acid, retinoid X receptor (RXR), forms heterodimers with several nuclear receptors, including the receptor for all-trans-retinoic acid, RAR. Previous studies have shown that retinoic acid receptor can be activated in RAR/RX

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THYROID-HORMONE RECEPTOR; LIGAND-BINDING DOMAIN; NUCLEAR RECEPTOR; CO-REPRESSOR; TRANSCRIPTIONAL ACTIVATION; RESPONSE PATHWAYS; CRYSTAL-STRUCTURE; LINE U-937; BETA-GENE; PROLIFERATION

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