Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP : an in vitro and in vivo study in the 5T33MM mouse model.

Nyckelord

Animals

Bone Marrow/metabolism

Cell Proliferation/drug effects

Comparative Study

Disease Models; Animal

Enzyme Activation

In Vitro

Insulin-Like Growth Factor I/pharmacology

Mice

Mice; Inbred C57BL

Microcirculation

Mitogen-Activated Protein Kinase 1/antagonists & inhibitors/metabolism

Multiple Myeloma/blood supply/*drug therapy/metabolism

Neovascularization; Pathologic/metabolism

Paraproteins/metabolism

Phosphorylation

Podophyllotoxin/*analogs & derivatives/pharmacology

Receptor; IGF Type 1/*antagonists & inhibitors/metabolism

Research Support; Non-U.S. Gov't

Survival Rate

Tumor Cells; Cultured

Vascular Endothelial Growth Factor A

Publikations- och innehållstyp

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