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Antithrombin reduct...
Antithrombin reduction after experimental cardiopulmonary resuscitation
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- Johansson, Jakob (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Anaesthesiology and Intensive Care
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- Ridefelt, Peter (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Clinical chemistry
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- Basu, Samar (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical nutrition
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- Rubertsson, Sten (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: Resuscitation. - 0300-9572 .- 1873-1570. ; 59:2, s. 229-236
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To determine whether activation of coagulation and inflammation during cardiac arrest results in a reduction of antithrombin (AT) and an increase in thrombin-antithrombin (TAT) complex during reperfusion.METHODS: Ventricular fibrillation (VF) was induced in ten anaesthetized pigs. After a 5-min non-intervention interval, closed-chest cardiopulmonary resuscitation (CPR) was performed for 9 min before defibrillation was attempted. If restoration of spontaneous circulation (ROSC) was achieved, the animals were observed for 4 h and repeated blood samples were taken for assay of AT, TAT and eicosanoids (8-iso-PGF(2alpha) and 15-keto-dihydro-PGF(2alpha)).RESULTS: AT began to decrease 15 min after ROSC and the reduction continued throughout the observation period (P<0.05). The lowest mean value (79%) occurred 60 min after ROSC. The TAT level was increased during the first 3 h after ROSC (P<0.05), indicating thrombin generation. The eicosanoids were increased throughout the observation period (P<0.05).CONCLUSIONS: AT is reduced and TAT and eicosanoids are increased after cardiac arrest, indicating activation of coagulation and inflammation.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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