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Development of depr...
Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene
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- Sjöberg, Rickard L (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Västerås, Sweden
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- Nilsson, Kent W. (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Västerås, Sweden
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- Nordquist, Niklas (författare)
- Uppsala universitet,Farmakologi,Uppsala universitet, Sweden
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- Öhrvik, John (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning, Västerås,Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Västerås, Sweden
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- Leppert, Jerzy (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Centre for Clinical Research, Uppsala University, Central Hospital Västerås, Västerås, Sweden
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- Lindström, Leif (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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- Oreland, Lars (författare)
- Uppsala universitet,Farmakologi,Uppsala universitet, Sweden
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(creator_code:org_t)
- Uppsala Univ, Cent Hosp Vasteras, Clin Res Ctr, S-72189 Vasteras, Sweden. Univ Uppsala, Pharmacol Unit, Dept Neurosci, Uppsala, Sweden. CAMBRIDGE UNIV PRESS, 2006
- 2006
- Engelska.
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Ingår i: International Journal of Neuropsychopharmacology. - Uppsala Univ, Cent Hosp Vasteras, Clin Res Ctr, S-72189 Vasteras, Sweden. Univ Uppsala, Pharmacol Unit, Dept Neurosci, Uppsala, Sweden. : CAMBRIDGE UNIV PRESS. - 1461-1457 .- 1469-5111. ; 9:4, s. 443-449
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Abstract
Ämnesord
Stäng
- Previous research has demonstrated that a polymorphism in the serotonin transporter gene (5-HTTLPR) and adverse psychosocial circumstances interact to predict depression. The purpose of the present study was to explore the extent to which sex modulates these effects. Eighty-one boys and 119 girls (16-19 years old) were interviewed about psychosocial background variables and genotyped for the 5-HTT promoter polymorphism. There were two main results. First, boys and girls carrying the short 5-HTTLPR allele react to different kinds of environmental factors. Whereas males were affected by living in public housing rather than in own owned homes and by living with separated parents, females were affected by traumatic conflicts within the family. Second, the responses of males and females carrying the short 5-HTTLPR allele to environmental stress factors go in opposite directions. Thus, whereas females tend to develop depressive symptoms, males seem to be protected from depression. The results suggest that both the molecular and the psychosocial mechanisms underlying depression may differ between boys and girls.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- depression
- gene-environment interaction
- genotype
- phenotype
- sex characteristics
- PHARMACY
- FARMACI
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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