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Gene expression ana...
Gene expression analysis identifies a genetic signature potentially associated with response to alpha-IFN in chronic phase CML patients
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- Hagberg, Anette (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Olsson-Strömberg, Ulla (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Blodsjukdomar
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- Wickenberg-Bolin, Ulrika (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Göransson, Hanna (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Cancer Pharmacology and Informatics
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- Isaksson, Anders (author)
- Uppsala universitet,Institutionen för genetik och patologi,Cancer Pharmacology and Informatics
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- Bengtsson, Mats (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Höglund, Martin (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
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- Simonsson, Bengt (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologi
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- Barbany, Gisela (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för genetik och patologi
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Leukemia Research. - : Elsevier BV. - 0145-2126 .- 1873-5835. ; 31:7, s. 931-938
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Microarray-based gene expression analysis was performed on diagnostic chronic phase CML patient samples prior to interferon treatment. Fifteen patient samples corresponding to six cytogenetic responders and nine non-responders were included. Genes differentially expressed between responder and non-responder patients were listed and a subsequent leave-one-out cross validation (LOOV) procedure showed that the top 20 genes allowed the highest prediction accuracy. The relevant genes were quantified by real-time PCR that supported the microarray results. We conclude that it might be possible to use gene expression analysis to predict future response to interferon in CML diagnostic samples.
Keyword
- Chronic myeloid leukemia
- Gene expression profiling
- Interferon
- Microarray
- Drug response
- RNASE2
- CEBP
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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