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Insulin sensitivity...
Insulin sensitivity measured with euglycemic clamp is independently associated with glomerular filtration rate in a community-based cohort
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- Nerpin, Elisabet (författare)
- Högskolan Dalarna,Medicinsk vetenskap
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- Risérus, Ulf (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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- Ingelsson, Erik (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics
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- Sundström, Johan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Jobs, Magnus (författare)
- Högskolan Dalarna,Medicinsk vetenskap
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- Larsson, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Basu, Samar (författare)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
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- Ärnlöv, Johan (författare)
- Högskolan Dalarna,Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Geriatrics,Medicinsk vetenskap
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(creator_code:org_t)
- American Diabetes Association, 2008
- 2008
- Engelska.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 31:8, s. 1550-1555
- Relaterad länk:
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http://care.diabetes...
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http://care.diabetes...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective: To investigate the association between insulin sensitivity and glomerular filtration rate (GFR) in the community, with pre-specified subgroup analyses in normoglycemic individuals with normal GFR. Research Design and Methods: We investigated the cross-sectional association between insulin sensitivity (M/I, assessed using euglycemic clamp) and cystatin C-based GFR in a community-based cohort of elderly men (Uppsala Longitudinal Study of Adult Men, ULSAM; n=1070). We also investigated whether insulin sensitivity predicted the incidence of renal dysfunction at a follow-up examination after 7 years. Results: Insulin sensitivity was directly related to GFR (multivariable-adjusted regression coefficient for 1-unit higher M/I 1.19, 95% CI 0.69-1.68, p<0.001) after adjusting for age, glucometabolic variables (fasting plasma glucose, fasting plasma insulin, 2-hour glucose after an oral glucose tolerance test), cardiovascular risk factors (hypertension, dyslipidemia, smoking), and lifestyle factors (BMI, physical activity, consumption of tea, coffee and alcohol). The positive multivariable-adjusted association between insulin sensitivity and GFR remained statistically significant also in participants with normal fasting plasma glucose, normal glucose tolerance and normal GFR (n=443, p<0.02). In longitudinal analyses, higher insulin sensitivity at baseline was associated with lower risk of impaired renal function (GFR<50ml/min/1.73 m2) during follow-up independently of glucometabolic variables (multivariable-adjusted odds ratio for 1-unit higher of M/I 0.58, 95 % CI 0.40-0.84, p<0.004). Conclusion: Our data suggest that impaired insulin sensitivity may be involved in the development of renal dysfunction at an early stage, prior to the onset of diabetes or pre-diabetic glucose elevations. Further studies are needed in order to establish causality.
Nyckelord
- hyperinsulinemic clamp
- insulin sensitivity
- cystatin C
- glomerular filtration rate
- chronic kidney disease
- Nedsatt njurfunktion, insulinresistens, oxidativ stress och utvecklingen av hjärt-kärlsjukdomar
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)
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