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A Cystatin C-based ...
A Cystatin C-based glomerular filtration rate equation is a stronger predictor of cardiovascular mortality compared to creatinine-based equations
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- Nerpin, Elisabet (författare)
- Högskolan Dalarna,Medicinsk vetenskap
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Ingelsson, Erik (författare)
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Riserus, Ulf (författare)
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Sundström, Johan (författare)
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Larsson, Anders (författare)
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Hallan, Stein (författare)
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Zethelius, Björn (författare)
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Berglund, Lars (författare)
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Basu, Samar (författare)
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Ärnlöv, Johan (författare)
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(creator_code:org_t)
- Göteborg, 2010
- 2010
- Svenska.
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Ingår i: Svenska Kardiovasculära vårmötet. - Göteborg.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Background: Several prior studies report that decreased estimated glomerular filtration rate (eGFR) predicts cardiovascular disease in the general population, but this is less studied in a primary preventive setting. Currently, various methods are available to assess eGFR. In the present study, we aimed to evaluate different eGFR-equations (creatinine-based or cystatin C-based), for the prediction of cardiovascular death. Material and methods: In men without cardiovascular disease, participating in the community-based Uppsala Longitudinal Study of Adult Men (ULSAM, n=649, mean age 71 years, median follow-up 12.9 years; 86 cardiovascular deaths during follow-up), eGFR was calculated from circulating creatinine by using the Modification of Diet in Renal Disease formula (eGFRMDRD) and the Chronic Kidney Disease Epidemiology Collaboration formula (eGFRCKD-EPI) and from circulating cystatin C using the following formula: 77.24x-1.2623 (eGFRcyst). Results: In Cox-proportional hazard models, 1-SD increase in eGFRcyst was associated with lower risk of cardiovascular mortality after adjustment for established cardiovascular risk factors and urinary albumin excretion rate (hazard ratio 0.74, 95% CI 0.59-0.92 (p=0.007). However, the creatinine-based GFR equations were not significantly associated with cardiovascular death (for eGFRMDRD: hazard ratio 0.84, 95% CI 0.67-1.06, (p=0.14), for eGFRCKD-EP : hazard ratio 0.86, 95% CI 0.69-1.07 (p=0.17)) in multivariable models. Moreover, when eGFRcyst was incorporated to a model with established risk factors, the integrated discrimination improvement was significantly increased 0.015, (p=0.02). Also eGFRcyst, provided improved discrimination beyond established risk factors and urinary albumine excretion rate (0.012, p=0.03). No improvement in integrated discrimination were seen with eGFRMDRD (p=0.25) or eGFRCKD-EPI (p=0.36). Conclusion: In our community-based cohort of elderly men free from cardiovascular disease at baseline, eGFRcyst significantly predicted cardiovascular death while the creatinine-based eGFR-equations did not. The fact that eGFRcyst improved model discrimination beyond established cardiovascular risk factors suggest that it may be a relevant risk marker for cardiovascular death in the elderly.
Nyckelord
- Cystatin C
- Glomerular filtration rate
- cardiovascular mortality
- Nedsatt njurfunktion, insulinresistens, oxidativ stress och utvecklingen av hjärt-kärlsjukdomar
Publikations- och innehållstyp
- vet (ämneskategori)
- kon (ämneskategori)
- Av författaren/redakt...
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Nerpin, Elisabet
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Ingelsson, Erik
-
Riserus, Ulf
-
Sundström, Johan
-
Larsson, Anders
-
Hallan, Stein
-
visa fler...
-
Zethelius, Björn
-
Berglund, Lars
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Basu, Samar
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Ärnlöv, Johan
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visa färre...
- Artiklar i publikationen
- Svenska Kardiova ...
- Av lärosätet
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Högskolan Dalarna