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CDKN2A germ-line mu...
CDKN2A germ-line mutations in individuals with multiple cutaneous melanomas.
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- Hashemi, J (författare)
- Karolinska Institutet
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Platz, A (författare)
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Ueno, T (författare)
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- Stierner, Ulrika, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för onkologi,Institute of Selected Clinical Sciences, Department of Oncology
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- Ringborg, U (författare)
- Karolinska Institutet
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- Hansson, J (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2000
- 2000
- Engelska.
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Ingår i: Cancer research. - 0008-5472. ; 60:24, s. 6864-7
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Germ-line CDKN2A mutations are present in some kindreds with hereditary cutaneous melanoma, and in Sweden a founder mutation with an extra arginine in codon 113 (113insR) has been identified. We screened 80 individuals with at least two primary cutaneous melanomas, who were identified mainly by a search of a regional cancer registry, for germ-line CDKN2A mutations. In nine patients, CDKN2A alterations that may contribute to melanoma predisposition were detected. In six individuals with a family history of melanoma, the 113insR founder mutation was present. One patient, who also had a family history of melanoma, had a 24-bp deletion that included codons 62-69. An in vitro binding assay established that the resulting mutant p16 protein was unable to bind cyclin-dependent kinase 4 and cyclin-dependent kinase 6. Two patients without a family history of melanoma had CDKN2A alterations: (a) one had a mutation in the 5' noncoding sequence (-14C/T); and (b) the other had an insertion of an extra T in codon 28, which results in a stop signal in codon 43. The median age at diagnosis of the first melanoma was significantly lower, the number of primary melanomas was significantly higher, and the presence of a family history of melanoma was significantly more common in patients with CDKN2A mutations than in those without germ-line mutations. The proportion of CDKN2A mutation carriers was significantly higher among patients treated for three or more primary melanomas compared with those with two tumors only. We conclude that mutation screening of individuals with multiple primary melanomas is a useful strategy to identify new melanoma kindreds with CDKN2A germ-line mutations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Age of Onset
- Base Sequence
- Codon
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase 6
- Cyclin-Dependent Kinase Inhibitor p16
- metabolism
- Cyclin-Dependent Kinases
- metabolism
- DNA
- Complementary
- metabolism
- Exons
- Family Health
- Female
- Founder Effect
- Gene Deletion
- Genes
- p16
- genetics
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Humans
- Male
- Melanoma
- genetics
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymorphism
- Single-Stranded Conformational
- Protein Binding
- Protein-Serine-Threonine Kinases
- metabolism
- Proto-Oncogene Proteins
- Sequence Analysis
- DNA
- Skin Neoplasms
- genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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