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Prognostic and pred...
Prognostic and predictive value of centrally reviewed Ki-67 labeling index in postmenopausal women with endocrine-responsive breast cancer: results from Breast International Group Trial 1-98 comparing adjuvant tamoxifen with letrozole.
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Viale, Giuseppe (författare)
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Giobbie-Hurder, Anita (författare)
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Regan, Meredith M (författare)
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Coates, Alan S (författare)
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Mastropasqua, Mauro G (författare)
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Dell'Orto, Patrizia (författare)
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Maiorano, Eugenio (författare)
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MacGrogan, Gaëtan (författare)
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Braye, Stephen G (författare)
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Ohlschlegel, Christian (författare)
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Neven, Patrick (författare)
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Orosz, Zsolt (författare)
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Olszewski, Wojciech P (författare)
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Knox, Fiona (författare)
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Thürlimann, Beat (författare)
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Price, Karen N (författare)
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Castiglione-Gertsch, Monica (författare)
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Gelber, Richard D (författare)
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Gusterson, Barry A (författare)
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Goldhirsch, Aron (författare)
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- Wallgren, Arne, 1940 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. - 1527-7755. ; 26:34, s. 5569-75
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PURPOSE: To evaluate the prognostic and predictive value of Ki-67 labeling index (LI) in a trial comparing letrozole (Let) with tamoxifen (Tam) as adjuvant therapy in postmenopausal women with early breast cancer. PATIENTS AND METHODS: Breast International Group (BIG) trial 1-98 randomly assigned 8,010 patients to four treatment arms comparing Let and Tam with sequences of each agent. Of 4,922 patients randomly assigned to receive 5 years of monotherapy with either agent, 2,685 had primary tumor material available for central pathology assessment of Ki-67 LI by immunohistochemistry and had tumors confirmed to express estrogen receptors after central review. The prognostic and predictive value of centrally measured Ki-67 LI on disease-free survival (DFS) were assessed among these patients using proportional hazards modeling, with Ki-67 LI values dichotomized at the median value of 11%. RESULTS: Higher values of Ki-67 LI were associated with adverse prognostic factors and with worse DFS (hazard ratio [HR; high:low] = 1.8; 95% CI, 1.4 to 2.3). The magnitude of the treatment benefit for Let versus Tam was greater among patients with high tumor Ki-67 LI (HR [Let:Tam] = 0.53; 95% CI, 0.39 to 0.72) than among patients with low tumor Ki-67 LI (HR [Let:Tam] = 0.81; 95% CI, 0.57 to 1.15; interaction P = .09). CONCLUSION: Ki-67 LI is confirmed as a prognostic factor in this study. High Ki-67 LI levels may identify a patient group that particularly benefits from initial Let adjuvant therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Antineoplastic Agents
- therapeutic use
- Antineoplastic Agents
- Hormonal
- therapeutic use
- Breast Neoplasms
- Chemotherapy
- Adjuvant
- Cohort Studies
- Endocrine System
- Female
- Humans
- Ki-67 Antigen
- biosynthesis
- Nitriles
- therapeutic use
- Postmenopause
- Predictive Value of Tests
- Prognosis
- Proportional Hazards Models
- Tamoxifen
- therapeutic use
- Triazoles
- therapeutic use
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Viale, Giuseppe
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Giobbie-Hurder, ...
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Regan, Meredith ...
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Coates, Alan S
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Mastropasqua, Ma ...
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Dell'Orto, Patri ...
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visa fler...
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Maiorano, Eugeni ...
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MacGrogan, Gaëta ...
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Braye, Stephen G
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Ohlschlegel, Chr ...
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Neven, Patrick
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Orosz, Zsolt
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Olszewski, Wojci ...
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Knox, Fiona
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Thürlimann, Beat
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Price, Karen N
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Castiglione-Gert ...
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Gelber, Richard ...
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Gusterson, Barry ...
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Goldhirsch, Aron
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Wallgren, Arne, ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Journal of clini ...
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Göteborgs universitet