Search: id:"swepub:oai:gup.ub.gu.se/102904" >
Breast cancer incid...
Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study
-
- Orgeas, C (author)
- Dept of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
-
- Sanner, Karin (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
-
- Hall, Per (author)
- Karolinska Institutet
-
show more...
-
Conner, Peter (author)
-
- Holte, Jan (author)
- Carl von Linne Kliniken, Uppsala University Hospital, Uppsala, Sweden
-
Nilsson, Staffan, 1956 (author)
-
- Sundfeldt, Karin, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg
-
Persson, Ingemar (author)
-
Chia, Kee Seng (author)
-
- Wedren, Sara (author)
- Karolinska Institutet
-
- Dickman, Paul (author)
- Karolinska Institutet
-
- Czene, Kamilla (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
-
In: Am J Obstet Gynecol. - : Elsevier BV. - 0002-9378 .- 1097-6868. ; 200:1
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVE: To assess the impact of infertility treatment with causes of infertility on incidence of breast cancer. STUDY DESIGN: Historical prospective cohort study of 1135 women attending major university clinics for treatment of infertility in Sweden, 1961-1976. Women were classified as users of clomiphene citrate or gonadotropins, or a combination of both therapies. Standardized incidence ratios were calculated to estimate relative risk of breast cancer. RESULTS: We observed 54 cases of breast cancer during 1961-2004, which did not significantly exceed those expected. Users of high-dose clomiphene citrate had an almost 2-fold increased risk (standardized incidence ratio, 1.90; 95% confidence interval, 1.08-3.35). This association was more pronounced among women referred for nonovulatory factors, with 3-fold increased risk (standardized incidence ratio, 3.00; 95% confidence interval, 1.35-6.67). CONCLUSION: No overall increased risk for breast cancer was shown with infertility treatment. Women with nonovulatory causes treated with high-dose clomiphene citrate therapy may have an elevated risk for breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Adult
- Breast Neoplasms/*chemically induced/epidemiology
- Chorionic Gonadotropin/*adverse effects/therapeutic use
- Clomiphene/*adverse effects/therapeutic use
- Cohort Studies
- Female
- Fertility Agents
- Female/*adverse effects/therapeutic use
- Humans
- Incidence
- Infertility
- Female/*drug therapy
- Prospective Studies
- Sweden/epidemiology
- ovulation induction
- postmenopausal women
- fertility drugs
- risk
- therapy
- health
- carcinogenesis
- prevention
- pregnancy
- estrogens
- Incidence
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Orgeas, C
-
Sanner, Karin
-
Hall, Per
-
Conner, Peter
-
Holte, Jan
-
Nilsson, Staffan ...
-
show more...
-
Sundfeldt, Karin ...
-
Persson, Ingemar
-
Chia, Kee Seng
-
Wedren, Sara
-
Dickman, Paul
-
Czene, Kamilla
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
- Articles in the publication
-
Am J Obstet Gyne ...
- By the university
-
University of Gothenburg
-
Chalmers University of Technology
-
Uppsala University
-
Karolinska Institutet