Safety aspects of GH replacement.

• In adults, GH replacement therapy will often be maintained for decades. Owing to the long duration of GH replacement in many adults, it is essential to establish the long-term safety aspects of the treatment. In this review, studies that have investigated the safety profile of long-term GH replacement will be reviewed with an emphasis on studies based on data from the Pfizer International Metabolic Database (KIMS). These studies show that long-term GH replacement in adults is safe and that long-term GH replacement may even improve cardiovascular mortality and morbidity in GH-deficient adults.

Nyckelord

Adult

Cardiovascular Diseases

epidemiology

mortality

prevention & control

Databases

Factual

Diabetes Mellitus

Type 2

chemically induced

epidemiology

metabolism

Human Growth Hormone

administration & dosage

adverse effects

deficiency

Humans

Hypothalamic Neoplasms

epidemiology

Insulin

metabolism

International Cooperation

Neoplasm Recurrence

Local

epidemiology

Neoplasms

chemically induced

epidemiology

Pituitary Neoplasms

epidemiology

Risk Assessment

Risk Factors

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)