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Asthma control over...
Asthma control over 3 years in a real-life study.
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- Lundbäck, Bo, 1948 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Krefting Research Centre
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- Rönmark, Eva, 1953 (author)
- Umeå universitet,Gothenburg University,Göteborgs universitet,Krefting Research Centre,Yrkes- och miljömedicin
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- Lindberg, Anne (author)
- Umeå universitet,Lungmedicin
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Jonsson, Ann-Christin (author)
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Larsson, Lars-Gunnar (author)
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James, Mark (author)
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: Respiratory medicine. - : Elsevier BV. - 1532-3064 .- 0954-6111. ; 103:3, s. 348-55
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Abstract
Subject headings
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- This was a 3-year "real-life" study, during which patients' medication was increased and decreased to achieve sustained asthma control. Patients (282) were randomised to receive treatment with SAL 50microg, FP 250microg, or SFC 50/250microg via a Diskustrade mark inhaler, bid. A 12-month double-blind period was followed by a 2-year open phase. The physician increased or decreased patients' medication to achieve and maintain asthma control at regular clinical assessments using criteria based on the asthma treatment guidelines. On completion 73% (168/229) of the subjects were receiving SFC to maintain control of their asthma, compared with 21% (49/229) receiving FP and 5% (12/229) receiving SAL. Odds ratio for requiring increased treatment were 2.66 (p=0.002) for patients initially randomised to FP and 9.38 (p<0.0001) SAL, compared with SFC. Time until 25% of patients first required an increase in study medication was 6months for patients initially treated with SAL compared to 12months for FP and 21months for SFC. Symptoms and use of rescue medication improved first, followed rapidly by PEF with the greatest improvements occurring over the first year. Airway hyperresponsiveness continued to improve throughout the study. The majority of patients achieved and maintained control of asthma over a 3-year period with physician-driven medication changes. Patients treated with SFC were more likely to achieve control than patients treated with FP or SAL alone. Continuing improvements in airway hyperresponsiveness indicate the importance of maintaining treatment after clinical control of symptoms and lung function are achieved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Albuterol
- analogs & derivatives
- therapeutic use
- Androstadienes
- therapeutic use
- Asthma
- drug therapy
- physiopathology
- Bronchodilator Agents
- therapeutic use
- Double-Blind Method
- Drug Administration Schedule
- Drug Therapy
- Combination
- Family Practice
- Female
- Follow-Up Studies
- Forced Expiratory Volume
- drug effects
- Humans
- Logistic Models
- Lung
- physiopathology
- Male
- Middle Aged
- Nebulizers and Vaporizers
- Treatment Outcome
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
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