Current status of pathogenetic mechanisms in staphylococcal arthritis.

• Interactions between staphylococci and the joint tissues of the host lead typically to rapidly progressing and highly destructive processes. Staphylococci possess a vast arsenal of components and products that contribute to the pathogenesis of joint infection. Occasionally these compounds have overlapping activities and act either in concert or alone. Host responsiveness to staphylococcal infection displays an even more complex pattern. Most of the cells and molecules that participate in the innate immune system protect the host against bacteria. However, the staphylococci have developed systems that counteract endogenous protective mechanisms. Interestingly, certain cells and molecules of the acquired immune system potentiate the severity of infection by triggering exaggerated responses to the staphylococcal danger signals. This review deals with the intricate host-bacterium interactions that occur during experimental septic arthritis, and outlines potential preventive and treatment modalities.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

Animals

Arthritis

Infectious

immunology

microbiology

therapy

Chemokines

metabolism

Cytokines

metabolism

Immunity

Active

Joints

microbiology

Mice

Staphylococcal Infections

immunology

microbiology

therapy

Staphylococcus

classification

metabolism

pathogenicity

Treatment Outcome

Virulence Factors

metabolism

Publikations- och innehållstyp

ref (ämneskategori)

for (ämneskategori)