Inflammatory Response to Injectable Biomaterials for Stabilisation of Vertebral Compression Fractures

• Biomaterials used for stabilisation of compressed vertebraes due to osteoporosis are currently mainly based on conventional bone cement, polymethyl methacrylate (PMMA). New material alternatives based on fully ceramic materials, e.g. calcium aluminates cements (CAC), are under development. In this in vivo study the early inflammatory response elicited by both cured and uncured CAC and PMMA cement was investigated in a rat model. Titanium (Ti) and sham sites were used as controls. Cell viability, cell proliferation, inflammatory cell recruitment and pro inflammatory cytokine secretion of tumour necrosis factor alpha (TNF-á) and monocyte chemoattractant protein-1 (MCP-1) was evaluated. The experimental observation period was 1 day and the results showed that both of the cured cements were more biocompatible and revealed a smaller inflammatory response than Ti, contrary to the uncured cements which provoked a larger inflammatory response and higher cell death than Ti. The inflammatory responses revealed by cured CAC and PMMA had no significant difference.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomaterials Science (hsv//eng)

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