Gender-related long-term effects in adult rats by perinatal dietary ratio of n-6/n-3 fatty acids.

• Epidemiological studies in humans have shown that perinatal nutrition affects health later in life. We have previously shown that the ratio of n-6 to n-3 polyunsaturated fatty acids (PUFA) in the maternal diet affects serum leptin levels and growth of the suckling pups. The aim of the present study was to investigate the long-term effects of various ratios of the dietary n-6 and n-3 PUFA during the perinatal period on serum leptin, insulin, and triacylglycerol, as well as body growth in the adult offspring. During late gestation and throughout lactation, rats were fed an isocaloric diet containing 7 wt% fat, either as linseed oil (n-3 diet), soybean oil (n-6/n-3 diet), or sunflower oil (n-6 diet). At 3 wk of age, the n-6/n-3 PUFA ratios in the serum phospholipids of the offspring were 2.5, 8.3, and 17.5, respectively. After weaning, all pups were given a standard chow. At the 28th postnatal wk, mean body weight and fasting insulin levels were significantly increased in the rats fed the n-6/n-3 diet perinatally compared with the other groups. The systolic blood pressure and serum triacylglycerol levels were only increased in adult male rats of the same group. These data suggest that the balance between n-6 and n-3 PUFA during perinatal development affects several metabolic parameters in adulthood, especially in the male animals.

Nyckelord

Aging

blood

Animals

Animals

Newborn

Cholesterol

blood

Diet

Dose-Response Relationship

Drug

Fasting

blood

Fatty Acids

blood

Fatty Acids

Omega-3

administration & dosage

pharmacology

Fatty Acids

Omega-6

administration & dosage

pharmacology

Female

Fetus

Insulin

blood

Male

Phospholipids

blood

Pregnancy

Prenatal Exposure Delayed Effects

Rats

Rats

Sprague-Dawley

Sex Factors

Time Factors

Triglycerides

blood

pharmacology

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