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Trajectories leadin...
Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies.
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- Lundström, Sebastian (författare)
- Lund University,Lunds universitet,Rättspsykiatri, Malmö,Forskargrupper vid Lunds universitet,Forensic Psychiatry, Malmö,Lund University Research Groups
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Haworth, Claire M A (författare)
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Carlström, Eva (författare)
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- Gillberg, Christopher, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Mill, Jonathan (författare)
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- Råstam, Maria, 1948 (författare)
- Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Barn- och ungdomspsykiatri,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Child and Adolescent Psychiatry,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Hultman, Christina M (författare)
- Karolinska Institutet
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Ronald, Angelica (författare)
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- Anckarsäter, Henrik, 1966 (författare)
- Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Rättspsykiatri, Malmö,Forskargrupper vid Lunds universitet,Forensic Psychiatry, Malmö,Lund University Research Groups
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Plomin, Robert (författare)
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- Lichtenstein, Paul (författare)
- Karolinska Institutet
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Reichenberg, Abraham (författare)
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(creator_code:org_t)
- 2010-02-26
- 2010
- Engelska.
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Ingår i: Journal of Child Psychology and Psychiatry, and Allied Disciplines. - : Wiley. - 0021-9630 .- 1469-7610. ; 51:7, s. 850-856
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Despite extensive efforts, the causes of autism remain unknown. Advancing paternal age has been associated with various neurodevelopmental disorders. We aim to investigate three unresolved questions: (a) What is the association between paternal age and autism spectrum disorders (ASD)?; (b) Does paternal age moderate the genetic and environmental etiological factors for ASD? (c) Does paternal age affect normal variation in autistic-like traits? Methods: Two nationally representative twin studies from Sweden (n = 11, 122, assessed at age 9 or 12) and the UK (n = 13, 524, assessed at age 9) were used. Categorical and continuous measures of ASD, autistic-like traits and autistic similarity were calculated and compared over paternal age categories. Results: Both cohorts showed a strong association between paternal age and the risk for ASD. A U-shaped risk association could be discerned since the offspring of both the youngest and oldest fathers showed an elevation in the risk for ASD. Autistic similarity increased with advancing paternal age in both monozygotic and dizygotic twins. Both cohorts showed significantly higher autistic-like traits in the offspring of the youngest and oldest fathers. Conclusions: Phenomena associated with paternal age are clearly involved in the trajectories leading to autistic-like traits and ASD. Mechanisms influencing the trajectories might differ between older and younger fathers. Molecular genetic studies are now needed in order to further understand the association between paternal age and ASD, as well as normal variation in social, language, and repetitive behaviors in the general population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Causality
- Child
- Child Development Disorders
- Pervasive
- Epidemiology
- Genetics
- Psychology
- Cohort Studies
- Diseases in Twins
- Epidemiology
- Genetics
- Psychology
- Female
- Great Britain
- Humans
- Male
- Paternal Age
- Social Environment
- Sweden
- Autism spectrum disorders
- paternal age
- autistic traits
- behavioral genetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Lundström, Sebas ...
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Haworth, Claire ...
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Carlström, Eva
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Gillberg, Christ ...
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Mill, Jonathan
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Råstam, Maria, 1 ...
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visa fler...
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Hultman, Christi ...
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Ronald, Angelica
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Anckarsäter, Hen ...
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Plomin, Robert
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Lichtenstein, Pa ...
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Reichenberg, Abr ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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Journal of Child ...
- Av lärosätet
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Göteborgs universitet
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Lunds universitet
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Karolinska Institutet