Hepatitis B virus genotypes in Mongols and Australian Aborigines.

• Hepatitis B virus (HBV) is spread worldwide. Seven genotypes, A-G, have been described, differing by more than 8% of the genome. In eastern Asia and Oceania genotypes B and C are predominant. However, little is known about genotypes in Mongolia and Australian aborigines. We analysed the preS and S regions of HBV from 9 Mongols and 5 Australian Aborigines. All Mongolian strains were of genotype D and were most similar to Central Asian sequences. All the Australian strains were genetically of serotype ayw3, and could not be reliably classified by the S region analysis, but placed on a separate branch. By preS analysis, they were however clearly of genotype C. The 6-7% nucleotide difference from published Asian genotype C sequences suggests that they diverged from Asian genotype C branch more than 1000 years ago.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

Nyckelord

Asian Continental Ancestry Group

Australia

epidemiology

Genotype

Hepatitis B

ethnology

virology

Hepatitis B Surface Antigens

genetics

Hepatitis B virus

classification

genetics

Humans

Molecular Sequence Data

Mongolia

epidemiology

Oceanic Ancestry Group

Phylogeny

Polymorphism

Restriction Fragment Length

Sequence Analysis

DNA

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)