Liaison osseuse et propriétés biomécaniques améliorées par des modifications à léchelle micro- et nanoscopique d'une surface d'oxyde de titane traitée par laser

• The aim of the current article was to review the development of a novel concept based on the topological application of micro- and nanoscale surface features on titanium oxide surfaces in order to achieve bone bonding and increased stability of the bone-implant junction. The analysis consisted of removal torque measurements, qualitative and quantitative histology, and scanning and transmission electron microscopy in order to obtain a state-of-the-art characterization of osseointegration on the macro-, micro- and nanolevels. Short and long-term, experimental studies of partly laser-modified implants with micro- and nano-scale surface topographical features demonstrated a considerable increase in the biomechanical anchorage to bone. The results showed a significant increase in removal torque, a different fracture pattern, and ultrastructural and chemical coalescence between mineralized tissue and the nano-structured surface of the laser modified implant. Studies in soft tissues demonstrated biocompatibility, a degree of inflammation comparable to machined titanium and no adverse events. This surface modification is now in clinical use. The first clinical data shows that this new concept provides excellent short-term (1 year follow up) performance.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomaterials Science (hsv//eng)

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